Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs1143634

Hard Link
rs1143634 is a snp on gene IL1B (interleukin 1, beta)

GeneIL1B Chromosome number 2 Chromosome position 112832813
Alleles G/A (transliterated to +) Minor Allele A Minor Allele Frequency 0.1328
Notation +3954 315C>T Phe105= Clinical significance Orientation (dbSNP) - (negative/reverse strand)
SNP Function
Synonymous variant
Gene Function
The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4 T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T and B lymphocytes The protein encoded by this IL1B is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is processed to its active form by caspase 1. This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity.
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

REPORTED




DSL/ Opus Chip

REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

NOT CURATED




GWAS Curated

NOT CURATED





MOST RECENT SEARCHES:
rs1143684 (NQO2) | rs2071002 (LOC105374888) | rs2283725 (MAOA) | rs2129785 (BLMH) | rs686 (DRD1) | rs4532 (DRD1) | rs8192708 (PCK1) | rs2069812 (IL5) | rs1143634 (IL1B) | rs10402876 (C3) | rs104894226 (HRAS)

MOST FREQUENTLY SEARCHED:
rs9939609 (FTO) | rs1799941 (SHBG) | rs1801133 (MTHFR) | rs1801181 (CBS) | rs6025 (F5) | rs20541 (IL13) | rs2569191 (CD14) | rs4680 (COMT) | rs2235544 (DIO1) | rs2075252 (LRP2) | rs2187668 (HLA-DQA1)








LURP ™ IS A REGISTERED TRADEMARK ® OF DATAPUNK BIOINFORMATICS, LLC. COPYRIGHT © 2015, 2016, 2017, 2018, 2019 ALL RIGHTS RESERVED.    |    DEVELOPER BLOG     |