Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs174696

Hard Link
rs174696 is a snp on gene COMT (catechol-O-methyltransferase)

GeneCOMT Chromosome number 22 Chromosome position 19965653
Alleles A/C/T Minor Allele C Minor Allele Frequency 0.4809
Notation Clinical significance Orientation (dbSNP) + (positive/forward strand)
Gene Function
Catechol-O-methyltransferase (COMT) gene helps break down the neurotransmitters dopamine and norepinephrine. A defect due to certain variants in COMT will cause higher levels of dopamine due to slower breakdown, which can contribute to anxiety and insomnia. Individuals can be more susceptible to dopamine fluctuations, and therefore mood swings. People without COMT mutations are generally more even tempered. Studies of the COMT Val158Met polymorphism have shown the variant affects cognitive tasks rated as executive function, aggression, and working memory and ratings of subjective well-being. The Met158Met variant has also been found to influence the effect of aspirin and vitamin E to lower rates of incident CVD of 40%. COMT is implicated in ADD/ADHD and bipolar disorders. A functioning FOKI SNP in the VDR gene and/or supplementing with vitamin D enhances dopamine formation. COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. Catechol-estrogens like 4-OH estrone, and catechol-containing flavonoids are metabolised by this enzyme, and play a role in the risk of cancer.  
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

NOT REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

NOT REPORTED




DSL/ Opus Chip

NOT REPORTED




Opus 23 Curated

NOT CURATED




CLINVAR Curated

NOT CURATED




GWAS Curated

NOT CURATED





MOST RECENT SEARCHES:
rs10434128 (NR3C2) | rs12654778 (ADRB2) | rs2422148 (LOC105374812) | rs174696 (COMT) | rs2171363 (TPH2) | rs4760816 (TPH2) | rs4760750 (TPH2) | rs3771863 (LOC105374811) | rs10427255 () | rs41302905 (ABO) | rs657152 (ABO)

MOST FREQUENTLY SEARCHED:
rs9939609 (FTO) | rs1799941 (SHBG) | rs1801133 (MTHFR) | rs1801181 (CBS) | rs6025 (F5) | rs20541 (IL13) | rs2569191 (CD14) | rs4680 (COMT) | rs2235544 (DIO1) | rs2075252 (LRP2) | rs2844682 ()








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