This SNP is reported by one or more services.
|| G/A (transliterated to +)
||Minor Allele Frequency
||Gln144Arg +2044G/A R130Q
||Orientation (dbSNP)|| - (negative/reverse strand)
| IL13 is one of a class of immune hormones known as 'cytokines'. IL13 down-regulates the activity of white blood cells known as 'macrophages', and thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. Dietary lectins have been shown to produce immunologic reactions due to their ability to stimulate IL13. |
|Self-reported allergy (A) ~ Hodgkin's lymphoma (?) ~ IgE levels (A) ~ Psoriasis (G)|