Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs2171363

Hard Link
rs2171363 is a snp on gene TPH2 (tryptophan hydroxylase 2)

GeneTPH2 Chromosome number 12 Chromosome position 71966484
Alleles G/C/A (transliterated to +) Minor Allele G Minor Allele Frequency 0.4034
Notation 609-6035A>C Clinical significance Orientation (dbSNP) - (negative/reverse strand)
SNP Function
rs2171363 is found in a large intronic sequence approximately 30kb removed from the 5' regulatory sequence.
Gene Function
The TPH2 gene provides instructions for making a protein that enables the first step in the biosynthesis of serotonin, an important hormone and neurotransmitter. This step is also rate-limiting, which means that any reduction in efficiency of TPH2 will affect the rate of production of serotonin. TPH2 is primarily found in the neurons of the brain which are serotonergic, that is, the nerve cells which have nerve ending that release and are stimulated by serotonin. Drugs that alter serotonin levels are used in treating depression, generalized anxiety disorder and social phobia. Depletion of serotonin is common between disorders such as obsessive-compulsive disorder, depression and anxiety. 
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

NOT REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

NOT REPORTED




DSL/ Opus Chip

REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

NOT CURATED




GWAS Curated

NOT CURATED





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