Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs2236225

Hard Link
rs2236225 is a snp on gene MTHFD1 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase)

GeneMTHFD1 Chromosome number Chromosome position
Alleles (transliterated to +) Minor Allele Minor Allele Frequency
Notation G1958A Clinical significance Orientation (dbSNP) - (negative/reverse strand)
SNP Function
MTHFD1 a gene of folate metabolism that controls the use of folate as a methyl donor) are more likely to develop organ dysfunction when deprived of choline. Purine Nucleotide Biosynthesis: Synthesis of the first fully formed purine nucleotide, inosine monophosphate, IMP begins with 5-phospho-α-ribosyl-1-pyrophosphate, PRPP. Through a series of reactions utilizing ATP, tetrahydrofolate (THF) derivatives, glutamine, glycine and aspartate this pathway yields IMP. Because choline metabolism and folate metabolism intersect at the methylation of homocysteine, manipulations that limit folate availability also increase the use of choline as a methyl donor.
Gene Function
MTHFD1 encodes a protein that is central to the methylation cycle.  MTHFD1 actually performs three enzymatic functions involving the interconversion of tetrahydrofolate into the building blocks for the amino acid methionine and elements of DNA synthesis using niacinamide derivatives for activation and inhibition. Tetrahydrofolate is a cofactor in many reactions, especially in the metabolism of amino acids and nucleic acids and the formation of neurotransmitters by supplying reducing agents needed to convert biopterin.
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

REPORTED




DSL/ Opus Chip

REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

CURATED




GWAS Curated

NOT CURATED





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