Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs2283725

Hard Link
rs2283725 is a snp on gene MAOA (monoamine oxidase A)

GeneMAOA Chromosome number X Chromosome position 43700729
Alleles A/G/T Minor Allele A Minor Allele Frequency 0.4376
Notation ↑ 306+7301A>G Clinical significance Orientation (dbSNP) + (positive/forward strand)
SNP Function
Intronic.
Gene Function
Intolerance to methylfolate supplementation is due to slower breakdown of neurotransmitters including serotonin, dopamine, norepinephrine can lead to low/high levels causing mood swings, OCD, anxiety, aggression, insomnia and depression. Despite feeling depleted patients have a feeling of being overstimulated. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. This enzyme requires B2 (riboflavin) in sufficient levels to function normally. Because this is on the X chromosome, males will have only one allele and is why mutations have an enhanced effect. ACE deletions will also increase anxiety and lower frustration thresholds. 
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

NOT REPORTED




23andme V5

NOT REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

NOT REPORTED




DSL/ Opus Chip

REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

NOT CURATED




GWAS Curated

NOT CURATED





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