Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs2304277

Hard Link
rs2304277 is a snp on gene OGG1 (8-oxoguanine DNA glycosylase)

GeneOGG1 Chromosome number Chromosome position
Alleles (transliterated to +) Minor Allele Minor Allele Frequency
Notation 14453G>A Clinical significance Orientation (dbSNP) - (negative/reverse strand)
SNP Function
1.8Kb downstream of 3'UTR region. Post-transcriptional modifications, like potential illegitimate microRNA target sites, could alter normal OGG1 mRNA regulation. [PMID: 27015555]
Gene Function
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

NOT REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

NOT REPORTED




DSL/ Opus Chip

NOT REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

NOT CURATED




GWAS Curated

NOT CURATED





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