Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs2522129

Hard Link
rs2522129 is a snp on gene SIRT4 (sirtuin 4)

GeneSIRT4 Chromosome number 12 Chromosome position 120310110
Alleles G/T Minor Allele T Minor Allele Frequency 0.2091
Notation Clinical significance Orientation (dbSNP) + (positive/forward strand)
Gene Function
This gene provides instructions to make a member of the sirtuin family of proteins. Members of the sirtuin family are grouped into four classes. The functions of human sirtuins have not yet been determined. Studies suggest that the human sirtuins may function as regulatory proteins inside the cells. The protein encoded by this gene is included in class IV of the sirtuin family. All of the sirtuin family are niacinamide-nicotinamide metabolite dependent. Sirtuins have been implicated in influencing a wide range of cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Sirtuins can also control circadian clocks and the manufacture of mitochondria. SIRT4 is found in mitochondria, it needs vitamin B2, and functions uses ADP-ribosyltransferase, necessary to regulate the metabolism of amino acids as a method of controlling insulin secretion and regulating blood glucose levels.
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

NOT REPORTED




Ancestry DNA

NOT REPORTED




Genos Export for Promethease

NOT REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

NOT CURATED




GWAS Curated

NOT CURATED





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