Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs35829419

Hard Link
rs35829419 is a snp on gene NLRP3 (NLR family, pyrin domain containing 3)

GeneNLRP3 Chromosome number 1 Chromosome position 247425556
Alleles A/C Minor Allele A Minor Allele Frequency 0.0224
Notation Clinical significance Orientation (dbSNP) + (positive/forward strand)
Gene Function
NALP3 is a component of the innate immune system that functions as a pathogen recognition receptor  that recognizes pathogen-associated molecular patterns (PAMPs). NALP3 is expressed predominantly in macrophages and as a component of the 'inflammasome', detects products of damaged cells such as extracellular ATP and crystalline uric acid. Activated NALP3 in turn triggers an immune response. Mutations in the NLRP3 gene are associated a number of organ specific autoimmune diseases. Defects in this gene have also been linked to familial Mediterranean fever. In addition, the NALP3 inflammasome has a role in the pathogenesis of gout and neuroinflammation occurring in protein-misfolding diseases, such as Alzheimer's, Parkinson's, and prion diseases.
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

NOT REPORTED




23andme V5

NOT REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

REPORTED




DSL/ Opus Chip

NOT REPORTED




Opus 23 Curated

NOT CURATED




CLINVAR Curated

NOT CURATED




GWAS Curated

NOT CURATED





MOST RECENT SEARCHES:
rs151264360 (ENOSF1) | rs5742904 (APOB) | rs5853517 (MED12L) | rs2046934 (MED12L) | rs9275572 () | rs4349859 (LOC101929072) | Rs1801131 (MTHFR) | i5000294 (GIF) | rs35829419 (NLRP3) | rs2472553 (CHRNA2) | rs3811450 (CHRNB2)

MOST FREQUENTLY SEARCHED:
rs1799941 (SHBG) | rs9939609 (FTO) | rs1801133 (MTHFR) | rs1801181 (CBS) | rs6025 (F5) | rs20541 (IL13) | rs4680 (COMT) | rs2569191 (CD14) | rs2075252 (LRP2) | rs2235544 (DIO1) | rs2844682 ()








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