Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs6295

Hard Link
rs6295 is a snp on gene HTR1A (5-hydroxytryptamine (serotonin) receptor 1A)

GeneHTR1A Chromosome number Chromosome position
Alleles (transliterated to +) Minor Allele Minor Allele Frequency
Notation Clinical significance Orientation (dbSNP) - (negative/reverse strand)
Gene Function
This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers.
Pharmacogenomics
Citalopram (GG): Homozygosity for the rs6295 G is associated with lower response rate in patients treated for major depression * Olanzapine (CC): Associated with the ability to ameliorate impaired attention in patients with schizophrenia. * Paroxetine (C): C potentially associated with discontinuation syndrome in patients treated for anxiety or depression. * Perospirone (CC): Associated with the ability to ameliorate impaired attention in patients with schizophrenia.
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

REPORTED




Ancestry DNA

NOT REPORTED




Genos Export for Promethease

NOT REPORTED




DSL/ Opus Chip

REPORTED




Opus 23 Curated

NOT CURATED




CLINVAR Curated

NOT CURATED




GWAS Curated

NOT CURATED





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