Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs6591536

Hard Link
rs6591536 is a snp on gene OR5A1 (olfactory receptor, family 5, subfamily A, member 1)

GeneOR5A1 Chromosome number Chromosome position
Alleles (transliterated to +) Minor Allele Minor Allele Frequency
Notation N183D Asn183Asp Clinical significance Orientation (dbSNP) - (negative/reverse strand)
Gene Function
The OR5A1 gene provides instructions for making the olfactory receptor, family 5, subfamily A, member 1 protein. The receptors for the sense of smell, or olfactory receptors, interact with aromatic molecules in the nose that stimulate the sense of smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors. Olfactory receptors share a structural component with many neurotransmitter and hormone receptors, and are responsible for the recognition and conversion of odorant signals. The olfactory receptor gene family is the largest in the genome.  rs6591536, also known as N183D or Asn183Asp, is a SNP in the OR5A1 gene. A study found that individuals vary in their ability to smell various odors, largely due to variations in their olfactory receptors. Carriers of one or two rs6591536(G) alleles are twice as unlikely to detect a particular compound, β-ionone, than those with rs6591536(A;A) individuals. In fact, 96% of the observed variation in odor detection is caused by this single SNP, making it nearly a completely Mendelian trait. β-Ionone is a significant contributor to the aroma of roses, despite its relatively low concentration, and is an important fragrance chemical used in perfumery. People with high or low β-ionone sensitivity are found in all populations. Since rs6591536 determines β-ionone odor sensitivity, generally described as "floral", individual preferences may depend on a person's genotype at this SNP. The same study found that on average, people with high-sensitivity to this odor were more likely to prefer fragrances and household products containing β-ionone than those with low-sensitivity. With food products such as beverages and chocolates, people with high-sensitivity rated them lower than those with low-sensitivity. In general, those with low-sensitivity, i.e. having rs6591536(A;A), were less likely to perceive the β-ionone in scented household products or in foods.
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

REPORTED




DSL/ Opus Chip

REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

NOT CURATED




GWAS Curated

NOT CURATED





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