Lurp

Cross-platforn SNP explorer. By Peter D'Adamo, ND


rs7775228

Hard Link
rs7775228 is a snp on gene CHR6-LOC32658079 ()

GeneCHR6-LOC32658079 Chromosome number Chromosome position
Alleles (transliterated to +) Minor Allele Minor Allele Frequency
Notation T > C Clinical significance Orientation (dbSNP) - (negative/reverse strand)
SNP Function
cis-regulates HLA-DRB4
Gene Function
HLA-DQ2 (DQ2) is a serotype group within HLA-DQ (DQ) serotyping system. The serotype is determined by the antibody recognition of β2 subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ2 are encoded by the HLA-DQB1*02 allele group. This group currently contains two common alleles, DQB1*0201 and DQB1*0202. HLA-DQ2 and HLA-DQB1*02 are almost synonymous in meaning. DQ2 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. These isoforms, nicknamed DQ2.2 and DQ2.5, are also encoded by the DQA1*0201 and DQA1*0501 genes, respectively. DQ2 represents the second highest risk factor for coeliac disease, the highest risk is a close family member with disease. Juvenile diabetes (T1D) has a high association with DQ2.5 and there appears to be link between GSE and early onset male T1D. Anti-tTG antibodies are found elevated in a one-third of T1D patients[19][20] and there are indicators that Triticeae may be involved but the gluten protein is a type of globulin (Glb1).  rs7775228 is a SNP on chromosome 6 near the HLA-DQB1 gene, which is associated with allergic rhinitis and rheumatoid arthritis.
GWAS Pathologies
IgE grass sensitization (C) ~ Asthma (A)
This SNP is reported by one or more services.


23andme V3

REPORTED




23andme V4

REPORTED




23andme V5

REPORTED




Ancestry DNA

REPORTED




Genos Export for Promethease

NOT REPORTED




DSL/ Opus Chip

REPORTED




Opus 23 Curated

CURATED




CLINVAR Curated

NOT CURATED




GWAS Curated

CURATED





MOST RECENT SEARCHES:
rs5483 () | rs75932628 (TREM2) | rs80357906 (BRCA1) | rs28897672 (BRCA1) | rs2282679 (GC) | rs10741657 (CYP2R1) | rs7775228 (CHR6-LOC32658079) | rs7454108 (CHR6-LOC32713706) | rs2395182 (HLA-DRA) | rs1611131 () | rs2073837 ()

MOST FREQUENTLY SEARCHED:
rs9939609 (FTO) | rs1799941 (SHBG) | rs1801133 (MTHFR) | rs1801181 (CBS) | rs20541 (IL13) | rs6025 (F5) | rs2569191 (CD14) | rs4680 (COMT) | rs2235544 (DIO1) | rs2075252 (LRP2) | rs2187668 (HLA-DQA1)








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