Datapunk Opus23 | Francisella

Francisella

RANK: Genus

TAXONOMY: cellular organisms -> Bacteria -> Proteobacteria -> Gammaproteobacteria -> Thiotrichales -> Francisellaceae -> Francisella

OVERVIEW:

Short, rod-shaped or coccoid cells, 0.2–0.7 × 0.2 µm (Francisella tularensis subsp. tularensis, F. tularensis subsp. holarctica, and F. tularensis subsp. mediasiatica) or 0.7 × 1.7 µm (F. philomiragia and F. tularensis subsp. novicida) when examined during active growth, pleomorphism occurs thereafter. Gram negative, faintly staining. Endospores are not produced. Nonmotile. Aerobic, growth enhanced under microaerophilic conditions. Colonies are distinct, convex, pale white, and reach maximum size in 3–4 days. Cysteine (or cystine) is required for growth (F. tularensis subsp. tularensis, F. tularensis subsp. holarctica, and F. tularensis subsp. mediasiatica) or enhances growth (F. philomiragia and F. tularensis subsp. novicida). Weakly catalase positive. F. tularensis is oxidase negative and F. philomiragia oxidase positive (Kovacs modification). H2S is produced in cysteine-supplemented medium. Strains from both species, with the exception of F. tularensis subsp. mediasiatica, produce acid but no gas from d-glucose and maltose. Urease negative and no reduction of nitrate. Strains are characterized by a unique fatty acid composition; long-chain saturated and monosaturated C18 to C26 acids, relatively large amounts of saturated even-chain acids (C10:0, C14:0, and C16:0), and two long-chain hydroxy acids (C16:0 3OH and C18:0 3OH).Type species: Francisella tularensis

TAGS

Keystone	Core species	Type species	Pathogen	Dysbiosis associated	Flora/ commensal	Gut associated	Probiotic
Leanness	Obesity	Skin microbiome	Fecal distribution	Oral microbiome	Vaginal microbiome	Butyrate producer	Catalase producer
Histamine producer	Food fermenter	Amylolytic	Propionate producer	Nitrifying

DESCENDANTS Francisella guangzhouensis Francisella halioticida Francisella hispaniensis Francisella noatunensis Francisella philomiragia Francisella tularensis environmental samples	INTERACTIONS	KEGG PATHWAYS 2-Oxocarboxylic acid metabolism ABC transporters Acarbose and validamycin biosynthesis Alanine, aspartate and glutamate metabolism Amino sugar and nucleotide sugar metabolism Aminoacyl-tRNA biosynthesis Aminobenzoate degradation Arachidonic acid metabolism Arginine and proline metabolism Arginine biosynthesis Bacterial secretion system Base excision repair Benzoate degradation Biosynthesis of amino acids Biosynthesis of antibiotics Biosynthesis of secondary metabolites Biosynthesis of unsaturated fatty acids Biotin metabolism Butanoate metabolism C5-Branched dibasic acid metabolism Carbon metabolism Cationic antimicrobial peptide (CAMP) resistance Chloroalkane and chloroalkene degradation Citrate cycle (TCA cycle) Cyanoamino acid metabolism Cysteine and methionine metabolism D-Alanine metabolism D-Glutamine and D-glutamate metabolism DNA replication Fatty acid biosynthesis Fatty acid degradation Fatty acid metabolism Folate biosynthesis Fructose and mannose metabolism Galactose metabolism Geraniol degradation Glutathione metabolism Glycerolipid metabolism Glycerophospholipid metabolism Glycine, serine and threonine metabolism Glycolysis / Gluconeogenesis Glyoxylate and dicarboxylate metabolism Histidine metabolism Homologous recombination Inositol phosphate metabolism Lipoic acid metabolism Lipopolysaccharide biosynthesis Lysine biosynthesis Lysine degradation Metabolic pathways Methane metabolism Microbial metabolism in diverse environments Mismatch repair Monobactam biosynthesis Nicotinate and nicotinamide metabolism Nitrogen metabolism Nitrotoluene degradation Nucleotide excision repair One carbon pool by folate Oxidative phosphorylation Pantothenate and CoA biosynthesis Pentose and glucuronate interconversions Pentose phosphate pathway Peptidoglycan biosynthesis Phenylalanine metabolism Phenylalanine, tyrosine and tryptophan biosynthesis Polyketide sugar unit biosynthesis Porphyrin and chlorophyll metabolism Propanoate metabolism Protein export Purine metabolism Pyrimidine metabolism Pyruvate metabolism Quorum sensing00253 RNA degradation RNA polymerase Riboflavin metabolism Ribosome Secondary bile acid biosynthesis Selenocompound metabolism Starch and sucrose metabolism Streptomycin biosynthesis Sulfur metabolism Sulfur relay system Taurine and hypotaurine metabolism Terpenoid backbone biosynthesis Thiamine metabolism Tryptophan metabolism Two-component system Ubiquinone and other terpenoid-quinone biosynthesis Valine, leucine and isoleucine biosynthesis Valine, leucine and isoleucine degradation Vancomycin resistance Vitamin B6 metabolism alpha-Linolenic acid metabolism beta-Alanine metabolism beta-Lactam resistance CLUSTERS WITH	METABOLOMICS NUTRIENTS/ SUBSTRATES ENDPRODUCTS INHIBITED BY ENHANCED BY BIOTRANSFORMS BIOTRANFORM
ANTIBIOTIC RESISTANCE Tetracycline (tetc)	BIOFILM FORMERS Francisella noatunensis Francisella philomiragia Francisella novicida	COGEM PATHOGENICITY Francisella tularensis (3) Francisella philomiragia (2) Francisella novicida (2)

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