Datapunk Opus23 | Megasphaera

Megasphaera

RANK: Genus

TAXONOMY: Bacteria -> Terrabacteria group -> Firmicutes -> Negativicutes -> Selenomonadales -> Veillonellaceae -> Megasphaera

OVERVIEW:

'Megasphaera' is a genus of Firmicutes bacteria classified within the class Negativicutes.Anaerobic. Gram-stain-negative cocci, 0.4–2.0 µm or more in diameter. Nonmotile. Endospores not formed. Glucose, fructose, and lactate may or may not be fermented. Gas may or may not be produced. Gelatin or milk is not hydrolysed and nitrate is not reduced. Pyruvate but not succinate is utilized. Common metabolic end products of all five species described are acetic, propionic, butyric, and valeric acid. Found in the rumen of cattle and sheep, in the feces and intestine of man, in human clinical samples, and in spoiled bottled beer.DNA G+C content (mol%): 42.4–46.4 (Tm), 53.6 (Bd).Type species: Megasphaera elsdenii

This genus contains microbial species that can reside in the human gastrointestinal tract. [PMC 4262072]

Microbial Abundance Data: Megasphaera (Percent of total population with standard deviation [PMID: 22698087])
Group 1				Group 2					Group 3			Group 4
Group 1 Avg	Buccal Mucosa	Keratinized Gingiva	Hard Palate	Group 2 Avg	Throat	Throat	Tonsils	Saliva	Group 3 Avg	Supragingival Plaque	Subgingival Plaque	Stool
0.129 % (0.236)	0.061 % (0.130)	0.011 % (0.062)	0.314 % (0.515)	0.602 % (0.767)	0.735 % (0.944)	0.426 % (0.599)	0.438 % (0.578)	0.810 % (0.947)	0.030 % (0.193)	0.012 % (0.078)	0.048 % (0.308)	0.040 % (0.245)

TAGS

Keystone	Core species	Type species	Pathogen	Dysbiosis associated	Flora/ commensal	Gut associated	Probiotic
Leanness	Obesity	Skin microbiome	Fecal distribution	Oral microbiome	Vaginal microbiome	Butyrate producer	Catalase producer
Histamine producer	Food fermenter	Amylolytic	Propionate producer	Nitrifying

DESCENDANTS Megasphaera cerevisiae Megasphaera elsdenii Megasphaera genomosp. C1 Megasphaera hominis Megasphaera indica Megasphaera massiliensis Megasphaera micronuciformis Megasphaera paucivorans Megasphaera sp. BS-4 Megasphaera sp. BV3C16-1 Megasphaera sp. DNF00872 Megasphaera sp. DNF00912 Megasphaera sp. S6-MB2 Megasphaera sp. TrE9262 Megasphaera sp. UPII 135-E Megasphaera sp. UPII 199-6 Megasphaera sp. oral taxon 123 Megasphaera sueciensis environmental samples	INTERACTIONS	KEGG PATHWAYS 2-Oxocarboxylic acid metabolism ABC transporters Acarbose and validamycin biosynthesis Alanine, aspartate and glutamate metabolism Amino sugar and nucleotide sugar metabolism Aminoacyl-tRNA biosynthesis Aminobenzoate degradation Arachidonic acid metabolism Arginine and proline metabolism Arginine biosynthesis Bacterial secretion system Base excision repair Benzoate degradation Biosynthesis of amino acids Biosynthesis of antibiotics Biosynthesis of secondary metabolites Biosynthesis of unsaturated fatty acids Biotin metabolism Butanoate metabolism C5-Branched dibasic acid metabolism Carbapenem biosynthesis Carbon metabolism Cationic antimicrobial peptide (CAMP) resistance Chloroalkane and chloroalkene degradation Citrate cycle (TCA cycle) Cyanoamino acid metabolism Cysteine and methionine metabolism D-Alanine metabolism D-Glutamine and D-glutamate metabolism DNA replication Degradation of aromatic compounds Fatty acid biosynthesis Fatty acid degradation Fatty acid metabolism Folate biosynthesis Fructose and mannose metabolism Galactose metabolism Glutathione metabolism Glycerolipid metabolism Glycerophospholipid metabolism Glycine, serine and threonine metabolism Glycolysis / Gluconeogenesis Glyoxylate and dicarboxylate metabolism Histidine metabolism Homologous recombination Lipopolysaccharide biosynthesis Lysine biosynthesis Lysine degradation Metabolic pathways Methane metabolism Microbial metabolism in diverse environments Mismatch repair Monobactam biosynthesis Naphthalene degradation Nicotinate and nicotinamide metabolism Nitrogen metabolism Novobiocin biosynthesis Nucleotide excision repair One carbon pool by folate Oxidative phosphorylation Pantothenate and CoA biosynthesis Pentose and glucuronate interconversions Pentose phosphate pathway Peptidoglycan biosynthesis Phenylalanine metabolism Phenylalanine, tyrosine and tryptophan biosynthesis Phosphonate and phosphinate metabolism Phosphotransferase system (PTS) Polyketide sugar unit biosynthesis Porphyrin and chlorophyll metabolism Propanoate metabolism Protein export Purine metabolism Pyrimidine metabolism Pyruvate metabolism Quorum sensing00253 RNA degradation RNA polymerase Riboflavin metabolism Ribosome Selenocompound metabolism Starch and sucrose metabolism Streptomycin biosynthesis Styrene degradation Sulfur metabolism Sulfur relay system Taurine and hypotaurine metabolism Terpenoid backbone biosynthesis Thiamine metabolism Tryptophan metabolism Two-component system Tyrosine metabolism Ubiquinone and other terpenoid-quinone biosynthesis Valine, leucine and isoleucine biosynthesis Valine, leucine and isoleucine degradation Vancomycin resistance Vitamin B6 metabolism beta-Alanine metabolism beta-Lactam resistance CLUSTERS WITH	METABOLOMICS NUTRIENTS/ SUBSTRATES ENDPRODUCTS INHIBITED BY ENHANCED BY BIOTRANSFORMS BIOTRANFORM
ANTIBIOTIC RESISTANCE Tetracycline (tetw) Tetracycline (teto)	BIOFILM FORMERS	COGEM PATHOGENICITY Megasphaera elsdenii (2)

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