RANK: Genus

TAXONOMY: Bacteria -> Terrabacteria group -> Firmicutes -> Tissierellia -> Tissierellales -> Peptoniphilaceae -> Peptoniphilus


The name Peptoniphilus derives from: 'friend of peptone', referring to the use of peptone as a major energy source. Peptoniphilus are gram positive anaerobic cocci that were formerly classified in the genus Peptostreptococcus. They are non-saccharolytic, use peptone as a major energy source and produce butyrate.This genus is part of the vaginal and gut microbiota. They have been reported to as present in diabetic skin and soft tissue infections, bone and joint infections, surgical site infections, chorioamnionitis and bloodstream infections. They are typically found as part of polymicrobial infections but are difficult to recover with usual clinical cultures. They have been increasingly reported with the more widespread use of 16S PCR and MALDI-TOF for identification. Peptoniphilus spp. are Gram-positive anaerobic cocci (GPAC) that were formerly classified in the genus Peptostreptococcus. Non-spore-forming, obligately anaerobic, Gram-stain-positive, cocci. Cells may occur in pairs, short chains, tetrads, or small masses. Nonmotile. Optimal growth temperature is 37°C. The major metabolic end product from peptone yeast extract glucose (PYG) medium is butyric acid. Carbohydrates are not fermented. Use peptones and oligopeptide as major energy source. The position 1, position 3, and interpeptide bridge of peptidoglycan are alanine, l-ornithine, and d-glutamic acid (Li et al., 1992; Schleifer and Nimmermann, 1973; Weiss, 1981). DNA G+C content (mol%): 25–34 (Ezaki, 1982).

Type species: Peptoniphilus asaccharolyticus

This genus contains microbial species that can reside in the human gastrointestinal tract. [PMC 4262072]

Gut associated
Butyrate producer
Vaginal microbiome
Fecal distribution
Microbial Abundance Data: Peptoniphilus
Percent of total population with standard deviation [PMID: 22698087]. Percentages > 1% highlighted.
0.001 %
0.000 %
0.001 %
0.001 %
0.000 %
0.005 %
0.002 %
  • Candidatus Peptoniphilus massiliensis
  • Peptoniphilus asaccharolyticus
  • Peptoniphilus catoniae
  • Peptoniphilus coxii
  • Peptoniphilus duerdenii
  • Peptoniphilus gorbachii
  • Peptoniphilus grossensis
  • Peptoniphilus harei
  • Peptoniphilus indolicus
  • Peptoniphilus ivorii
  • Peptoniphilus koenoeneniae
  • Peptoniphilus lacrimalis
  • Peptoniphilus methioninivorax
  • Peptoniphilus obesi
  • Peptoniphilus olsenii
  • Peptoniphilus rhinitidis
  • Peptoniphilus senegalensis
  • Peptoniphilus sp. 1-14
  • Peptoniphilus sp. 2002-2300004
  • Peptoniphilus sp. 2002-38328
  • Peptoniphilus sp. 7-2
  • Peptoniphilus sp. BV3AC2
  • Peptoniphilus sp. DNF00192
  • Peptoniphilus sp. JCM 8143
  • Peptoniphilus sp. S4-13
  • Peptoniphilus sp. S4-14
  • Peptoniphilus sp. S4-A10
  • Peptoniphilus sp. S7MS8
  • Peptoniphilus sp. S9 PR-13
  • Peptoniphilus sp. gpac018A
  • Peptoniphilus sp. gpac148
  • Peptoniphilus sp. oral taxon 375
  • Peptoniphilus sp. oral taxon 836
  • Peptoniphilus stercorisuis
  • Peptoniphilus timonensis
  • Peptoniphilus tyrrelliae
  • environmental samples
    Substrates/ Growth Factors
  • Peptone

  • Metabolic Endproducts
  • Butyrate