TAXONOMY: Bacteria -> Terrabacteria group -> Firmicutes -> Tissierellia -> Tissierellales -> Peptoniphilaceae -> Peptoniphilus
The name Peptoniphilus derives from: 'friend of peptone', referring to the use of peptone as a major energy source. Peptoniphilus are gram positive anaerobic cocci that were formerly classified in the genus Peptostreptococcus. They are non-saccharolytic, use peptone as a major energy source and produce butyrate.This genus is part of the vaginal and gut microbiota. They have been reported to as present in diabetic skin and soft tissue infections, bone and joint infections, surgical site infections, chorioamnionitis and bloodstream infections. They are typically found as part of polymicrobial infections but are difficult to recover with usual clinical cultures. They have been increasingly reported with the more widespread use of 16S PCR and MALDI-TOF for identification. Peptoniphilus spp. are Gram-positive anaerobic cocci (GPAC) that were formerly classified in the genus Peptostreptococcus. Non-spore-forming, obligately anaerobic, Gram-stain-positive, cocci. Cells may occur in pairs, short chains, tetrads, or small masses. Nonmotile. Optimal growth temperature is 37°C. The major metabolic end product from peptone yeast extract glucose (PYG) medium is butyric acid. Carbohydrates are not fermented. Use peptones and oligopeptide as major energy source. The position 1, position 3, and interpeptide bridge of peptidoglycan are alanine, l-ornithine, and d-glutamic acid (Li et al., 1992; Schleifer and Nimmermann, 1973; Weiss, 1981). DNA G+C content (mol%): 25–34 (Ezaki, 1982).
Type species: Peptoniphilus asaccharolyticus
This genus contains microbial species that can reside in the human gastrointestinal tract. [PMC 4262072]