RANK: Genus

TAXONOMY: cellular organisms -> Bacteria -> Proteobacteria -> Betaproteobacteria -> Burkholderiales -> Sutterellaceae -> Sutterella


'Sutterella' is a genus of Gram-negative, anaerobic, nonspore-forming bacteria of the family Sutterellaceae which belongs to the class Betaproteobacteria; they were isolated from human feces. Sutterella cells were present in the intestines of children with autism, who also often suffer from digestive disturbances such as constipation and diarrhea, but absent from the intestines of children who did not have autism.  Increased abundance of Sutterella spp. and Ruminococcus torques in feces of children with autism spectrum disorder (ASD). The numbers of Sutterella spp. are elevated in feces of ASD children relative to controls, and that numbers of R. torques are higher in the children with ASD with a reported functional gastrointestinal disorder than those without such a disorder. [PMID: 24188502] Straight rod, 0.5–1 × 1–3 µm. Gram negative. Grows in a microaerophilic atmosphere (2% and 6% oxygen) or under anaerobic conditions. Isolated mainly from the intestinal tract and from infections of gastrointestinal origin. Urease negative. Oxidase negative. Indoxyl acetate negative. Reduces nitrate. Resistant to 20% bile disks. Asaccharolytic. Cannot reduce tetrazolium tetrachloride under aerobic conditions if formate and fumarate are added to the medium. May be resistant to metronidazole. Type species: Sutterella wadsworthensis

Sutterella does not appear to induce substantial inflammation; rather, it has a capacity to degrade IgA. [PMID: 32544438]

Alcaligenaceae (genus Sutterella) was significantly decreased in the ascending colon of patients with T2D and increased after RYGB surgery in the caecum of T2D rats as shown by a linear discriminant analysis effect size (LEfSe) analysis. Sutterella may have beneficial effects on glycometabolism in T2D patients after RYGB surgery. [PMID: 32194221]

Our analysis revealed nine different genera as differentially abundant in four study groups. Among them, Akkermansia, Blautia, and Ruminococcus were found to be significantly (P < 0.05) decreased, while Lactobacillus was increased in NewDMs compared to ND and recovered in KnownDMs. Akkermansia was inversely correlated with HbA1c and positively correlated with total antioxidants. Compared to ND, there was increased abundance of Megasphaera, Escherichia, and Acidaminococcus and decreased abundance of Sutterella in KnownDMs. Among many taxa known to act as community drivers during disease progression, we observed genus Sutterella as a common driver taxon among all diabetic groups. [PMID: 32234773] [PMCID: PMC7112960]

This genus contains microbial species that can reside in the human gastrointestinal tract. [PMC 4262072]

Gut associated
Flora/ commensal
Fecal distribution
Microbial Abundance Data: Sutterella
Percent of total population with standard deviation [PMID: 22698087]. Percentages > 1% highlighted.
0.002 %
0.000 %
0.005 %
0.040 %
0.000 %
0.003 %
0.796 %

Growth Inhibited by
  • Polymannuronic acid

  • Growth Enhanced By
  • Chemotherapy
  • High protein diet

  • Biotransforms
  • IgA
  • Ginsenoside Rb1