CB2 receptor expressionCannabinoid receptor type 2 is encoded by the CNR2 gene and is a member of the cannabinoid receptor family. Originally it was though that the CB2 receptor was only expressed in peripheral tissue while the CB1 receptor is the endogenous receptor on neurons.Recent work has shown that CB2 is also expressed on neurons. CB2 receptors are found on many immune system tissues including the spleen, tonsils, and thymus gland. They are also found in the brain, primarily on microglia cells. They are also found in the gastrointestinal system where they modulate intestinal inflammatory response and may be a potential target for inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis.
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