Bacteria: Chloramphenicol resistance


Chloramphenicol description

23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor

An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)

Chloramphenicol resistance gene: cml_e1