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Clostridium scindens

RANK: Species

TAXONOMY: Terrabacteria group -> Firmicutes -> Clostridia -> Clostridiales -> Lachnospiraceae -> Lachnoclostridium -> Clostridium scindens

OVERVIEW:

Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens. [http://www.ncbi.nlm.nih.gov/pubmed/23772041]Clostridium scindens sp. nov., an obligate anaerobe with desmolytic activity, was isolated from human fecal flora. The desmolase, not associated previously with any specific intestinal microorganism, cleaves the carbon-carbon bond of 17-hydroxylated corticoids at C17-C20, thereby converting them to androstans (C19 steroids). In primary cultures on sheep blood agar plates, C. scindens forms minute, nonhemdytic colonies. The gram-positive rods (0.5 to 0.7 by 1 to 2.5 pm) are slightly curved. The rare oval terminal spores (0.8 to 2.0 pm in diameter) are extremely difficult to demonstrate in Gram-stained smears. More than 40% of the cells are fimbriated. Neither a capsule nor flagella are present. D-Fructose, D-glucose, lactose, D-mannoae, D-ribose, and D-xylose are fermented. The major fermentation products are acetic acid, ethanol, and hydrogen. The type strain is ATCC 35704 (Bokkenheuser strain 19).

This species has been identified as a resident in the human gastrointestinal tract based on the phylogenetic framework of its small subunit ribosomal RNA gene sequences.[PMC 4262072]

COGEM
COGEM released a comprehensive database of pathogenicity assessment of around 2575 bacterial species in 2011. The database ranks the pathogenicity of species on a scale of 1 to 4. Clostridium scindens ranks on this scale:


TAGS
Keystone
Core species
Type species
Pathogen
Dysbiosis associated
Flora/ commensal
Gut associated
Probiotic
Leanness
Obesity
Skin microbiome
Fecal distribution
Oral microbiome
Vaginal microbiome
Butyrate producer
Catalase producer
Histamine producer
Food fermenter
Amylolytic
Propionate producer
Nitrifying
Biofilm producer
INTERACTIONS
KEGG PATHWAYS

CLUSTERS WITH
METABOLOMICS       
NUTRIENTS/ SUBSTRATES
  • D-Xylose
  • D-Ribose
  • D-Fructose
  • D-Maltose
  • D-Lactose

  • ENDPRODUCTS
    ANTIBIOTIC RESISTANCE   BIOFILM FORMERS   COGEM PATHOGENICITY   

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