SUBSTRATA MAIN PAGE


Blautia

RANK: Genus

TAXONOMY: Bacteria -> Terrabacteria group -> Firmicutes -> Clostridia -> Clostridiales -> Lachnospiraceae -> Blautia

OVERVIEW:

Blautia may assist in the digestion of complex carbohydrates. An abundance of these bacteria is a strong indication of a healthy gut. Blautia levels are increased in healthy people when compared to patients with liver disease and colorectal cancer and children with diabetes. The relationship between intestinal microbiota composition and acute graft-versus-host disease (GVHD) after allogeneic blood/marrow transplantation (allo-BMT) is not well understood. Intestinal bacteria have long been thought to contribute to GVHD pathophysiology, but recent animal studies in nontransplant settings have found that anti-inflammatory effects are mediated by certain subpopulations of intestinal commensals. Hypothesizing that a more nuanced relationship may exist between the intestinal bacteria and GVHD, we evaluated the fecal bacterial composition of 64 patients 12 days after BMT. We found that increased bacterial diversity was associated with reduced GVHD-related mortality. Furthermore, harboring increased amounts of bacteria belonging to the genus Blautia was associated with reduced GVHD lethality in this cohort and was confirmed in another independent cohort of 51 patients from the same institution. Blautia abundance was also associated with improved overall survival. We evaluated the abundance of Blautia with respect to clinical factors and found that loss of Blautia was associated with treatment with antibiotics that inhibit anaerobic bacteria and receiving total parenteral nutrition for longer durations. We conclude that increased abundance of commensal bacteria belonging to the Blautia genus is associated with reduced lethal GVHD and improved overall survival. PMID: 25977230

This genus contains microbial species that can reside in the human gastrointestinal tract. [PMC 4262072]

Specific differences have been found in blood group A-secretors demonstrating that the genus Blautia is lower in the group A-secretors compared with the non-A-secretors. [PMCID: PMC5625272]



Microbial Abundance Data: Blautia
(Percent of total population with standard deviation [PMID: 22698087])
Group 1
Group 2
Group 3
Group 4
Group 1 Avg
Buccal
Mucosa
Keratinized
Gingiva
Hard
Palate
Group 2 Avg
Throat
Throat
Tonsils
Saliva
Group 3 Avg
Supragingival
Plaque
Subgingival
Plaque
Stool
0.005 %
(0.023)
0.004 %
(0.014)
0.001 %
(0.006)
0.010 %
(0.049)
0.004 %
(0.017)
0.008 %
(0.027)
0.003 %
(0.022)
0.001 %
(0.007)
0.004 %
(0.013)
0.001 %
(0.011)
0.000 %
(0.000)
0.002 %
(0.023)
0.765 %
(0.956)
TAGS
Keystone
Core species
Type species
Pathogen
Dysbiosis associated
Flora/ commensal
Gut associated
Probiotic
Leanness
Obesity
Skin microbiome
Fecal distribution
Oral microbiome
Vaginal microbiome
Butyrate producer
Catalase producer
Histamine producer
Food fermenter
Amylolytic
Propionate producer
Nitrifying
Biofilm producer
DESCENDANTS
INTERACTIONS
ENHANCES
  • Bacteroidales
  • Bacteroides
  • Odoribacter
  • Peptococcaceae
  • Bacteroidales
  • Bacteroides
  • Odoribacter
  • Peptococcaceae
  • Bacteroidales
  • Bacteroides
  • Odoribacter
  • Peptococcaceae
  • Bacteroidales
  • Bacteroides
  • Odoribacter
  • Peptococcaceae

  • INHIBITS
  • Peptoclostridium
  • Bifidobacterium
  • Coriobacteriales
  • Adlercreutzia
  • Collinsella
  • Porphyromonas
  • Prevotella
  • Clostridium
  • Clostridiales incertae sedis
  • Clostridiales Family XIII. Incertae Sedis
  • Blautia
  • Coprococcus
  • Dorea
  • Lachnospiraceae
  • Ruminococcaceae
  • Ruminococcus
  • Dialister
  • Campylobacteraceae
  • Erysipelotrichaceae
  • Bifidobacterium
  • Coriobacteriales
  • Adlercreutzia
  • Collinsella
  • Porphyromonas
  • Prevotella
  • Clostridium
  • Clostridiales incertae sedis
  • Clostridiales Family XIII. Incertae Sedis
  • Blautia
  • Coprococcus
  • Dorea
  • Lachnospiraceae
  • Ruminococcaceae
  • Ruminococcus
  • Dialister
  • Campylobacteraceae
  • Erysipelotrichaceae
  • Bifidobacterium
  • Coriobacteriales
  • Adlercreutzia
  • Collinsella
  • Porphyromonas
  • Prevotella
  • Clostridium
  • Clostridiales incertae sedis
  • Clostridiales Family XIII. Incertae Sedis
  • Blautia
  • Coprococcus
  • Dorea
  • Lachnospiraceae
  • Ruminococcaceae
  • Ruminococcus
  • Dialister
  • Campylobacteraceae
  • Erysipelotrichaceae
  • Bifidobacterium
  • Coriobacteriales
  • Adlercreutzia
  • Collinsella
  • Porphyromonas
  • Prevotella
  • Clostridium
  • Clostridiales incertae sedis
  • Clostridiales Family XIII. Incertae Sedis
  • Blautia
  • Coprococcus
  • Dorea
  • Lachnospiraceae
  • Ruminococcaceae
  • Ruminococcus
  • Dialister
  • Campylobacteraceae
  • Erysipelotrichaceae

  • INHIBITED BY
  • Bifidobacterium
  • Bifidobacterium
  • Coriobacteriales
  • Coriobacteriales
  • Adlercreutzia
  • Adlercreutzia
  • Collinsella
  • Collinsella
  • Bacteroidales
  • Bacteroidales
  • Bacteroides
  • Bacteroides
  • Porphyromonadaceae
  • Porphyromonadaceae
  • Odoribacter
  • Odoribacter
  • Parabacteroides
  • Parabacteroides
  • Porphyromonas
  • Porphyromonas
  • Prevotella
  • Prevotella
  • Rikenellaceae
  • Rikenellaceae
  • Alistipes
  • Alistipes
  • Turicibacter
  • Turicibacter
  • Streptococcus
  • Streptococcus
  • Clostridiales
  • Clostridiales
  • Catabacteriaceae
  • Catabacteriaceae
  • Clostridium
  • Clostridium
  • Clostridiales incertae sedis
  • Clostridiales incertae sedis
  • Peptoniphilus
  • Peptoniphilus
  • Clostridiales Family XIII. Incertae Sedis
  • Clostridiales Family XIII. Incertae Sedis
  • Lachnospiraceae
  • Lachnospiraceae
  • Blautia
  • Blautia
  • Lachnospiraceae
  • Lachnospiraceae
  • Coprococcus
  • Coprococcus
  • Dorea
  • Dorea
  • Eubacterium
  • Eubacterium
  • Lachnobacterium
  • Lachnobacterium
  • Lachnospira
  • Lachnospira
  • Roseburia
  • Roseburia
  • Lachnospiraceae
  • Lachnospiraceae
  • Peptococcaceae
  • Peptococcaceae
  • Ruminococcaceae
  • Ruminococcaceae
  • Ruminiclostridium
  • Ruminiclostridium
  • Acetivibrio
  • Acetivibrio
  • Eubacterium
  • Eubacterium
  • Faecalibacterium
  • Faecalibacterium
  • Oscillospira
  • Oscillospira
  • Ruminococcus
  • Ruminococcus
  • Acidaminococcus
  • Acidaminococcus
  • Dialister
  • Dialister
  • Phascolarctobacterium
  • Phascolarctobacterium
  • Veillonella
  • Veillonella
  • Rubrivivax
  • Rubrivivax
  • Alcaligenaceae
  • Alcaligenaceae
  • Oxalobacter
  • Oxalobacter
  • Bilophila
  • Bilophila
  • Desulfovibrio
  • Desulfovibrio
  • Campylobacteraceae
  • Campylobacteraceae
  • Enterobacteriaceae
  • Enterobacteriaceae
  • Escherichia
  • Escherichia
  • Erysipelotrichaceae
  • Erysipelotrichaceae
  • Erysipelotrichaceae
  • Erysipelotrichaceae
  • Holdemania
  • Holdemania
  • Akkermansia
  • Akkermansia
  • KEGG PATHWAYS
  • 2-Oxocarboxylic acid metabolism
  • ABC transporters
  • Alanine, aspartate and glutamate metabolism
  • Amino sugar and nucleotide sugar metabolism
  • Aminoacyl-tRNA biosynthesis
  • Arginine and proline metabolism
  • Arginine biosynthesis
  • Ascorbate and aldarate metabolism
  • Bacterial chemotaxis
  • Bacterial secretion system
  • Base excision repair
  • Benzoate degradation
  • Biosynthesis of amino acids
  • Biosynthesis of antibiotics
  • Biosynthesis of secondary metabolites
  • Biosynthesis of siderophore group nonribosomal peptides
  • Biosynthesis of unsaturated fatty acids
  • Biotin metabolism
  • Butanoate metabolism
  • C5-Branched dibasic acid metabolism
  • Carbapenem biosynthesis
  • Carbon metabolism
  • Cationic antimicrobial peptide (CAMP) resistance
  • Chloroalkane and chloroalkene degradation
  • Citrate cycle (TCA cycle)
  • Cyanoamino acid metabolism
  • Cysteine and methionine metabolism
  • D-Alanine metabolism
  • D-Glutamine and D-glutamate metabolism
  • DNA replication
  • Degradation of aromatic compounds
  • Fatty acid biosynthesis
  • Fatty acid degradation
  • Fatty acid metabolism
  • Folate biosynthesis
  • Fructose and mannose metabolism
  • Galactose metabolism
  • Glutathione metabolism
  • Glycerolipid metabolism
  • Glycerophospholipid metabolism
  • Glycine, serine and threonine metabolism
  • Glycolysis / Gluconeogenesis
  • Glyoxylate and dicarboxylate metabolism
  • Histidine metabolism
  • Homologous recombination
  • Inositol phosphate metabolism
  • Insulin resistance
  • Lysine biosynthesis
  • Lysine degradation
  • Metabolic pathways
  • Methane metabolism
  • Microbial metabolism in diverse environments
  • Mismatch repair
  • Monobactam biosynthesis
  • Naphthalene degradation
  • Nicotinate and nicotinamide metabolism
  • Nitrogen metabolism
  • Novobiocin biosynthesis
  • Nucleotide excision repair
  • One carbon pool by folate
  • Other glycan degradation
  • Oxidative phosphorylation
  • Pantothenate and CoA biosynthesis
  • Pentose and glucuronate interconversions
  • Pentose phosphate pathway
  • Peptidoglycan biosynthesis
  • Phenylalanine metabolism
  • Phenylalanine, tyrosine and tryptophan biosynthesis
  • Phosphotransferase system (PTS)
  • Polyketide sugar unit biosynthesis
  • Porphyrin and chlorophyll metabolism
  • Propanoate metabolism
  • Protein export
  • Purine metabolism
  • Pyrimidine metabolism
  • Pyruvate metabolism
  • RNA degradation
  • RNA polymerase
  • Riboflavin metabolism
  • Ribosome
  • Secondary bile acid biosynthesis
  • Selenocompound metabolism
  • Sphingolipid metabolism
  • Starch and sucrose metabolism
  • Streptomycin biosynthesis
  • Sulfur metabolism
  • Sulfur relay system
  • Taurine and hypotaurine metabolism
  • Terpenoid backbone biosynthesis
  • Thiamine metabolism
  • Tryptophan metabolism
  • Two-component system
  • Tyrosine metabolism
  • Valine, leucine and isoleucine biosynthesis
  • Valine, leucine and isoleucine degradation
  • Vancomycin resistance
  • Vitamin B6 metabolism
  • beta-Alanine metabolism
  • beta-Lactam resistance

  • CLUSTERS WITH
    METABOLOMICS       
    NUTRIENTS/ SUBSTRATES

    ENDPRODUCTS
  • Butyrate [parent]
  • ANTIBIOTIC RESISTANCE   
    BIOFILM FORMERS   
    COGEM PATHOGENICITY   

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