Datapunk Opus23 | Fusobacterium

Fusobacterium

RANK: Genus

TAXONOMY: cellular organisms -> Bacteria -> Fusobacteria -> Fusobacteriia -> Fusobacteriales -> Fusobacteriaceae -> Fusobacterium

OVERVIEW:

Nonsporeforming rods that are Gram-stain-negative and obligately anaerobic. Metabolize peptone or carbohydrates in PY-glucose to produce butyrate, often with acetate and lower levels of lactate, propionate, succinate, and formate. DNA G+C content (mol%): 26–34.Type species: Fusobacterium nucleatum

This genus contains microbial species that can reside in the human gastrointestinal tract. [PMC 4262072]

Microbial Abundance Data: Fusobacterium (Percent of total population with standard deviation [PMID: 22698087])
Group 1				Group 2					Group 3			Group 4
Group 1 Avg	Buccal Mucosa	Keratinized Gingiva	Hard Palate	Group 2 Avg	Throat	Throat	Tonsils	Saliva	Group 3 Avg	Supragingival Plaque	Subgingival Plaque	Stool
2.703 % (2.997)	2.671 % (2.707)	2.240 % (3.377)	3.198 % (2.907)	7.276 % (5.981)	5.645 % (5.260)	9.802 % (7.413)	7.798 % (6.889)	5.861 % (4.361)	9.225 % (7.026)	6.454 % (5.646)	11.996 % (8.407)	0.067 % (0.492)

TAGS

Keystone	Core species	Type species	Pathogen	Dysbiosis associated	Flora/ commensal	Gut associated	Probiotic
Leanness	Obesity	Skin microbiome	Fecal distribution	Oral microbiome	Vaginal microbiome	Butyrate producer	Catalase producer
Histamine producer	Food fermenter	Amylolytic	Propionate producer	Nitrifying

DESCENDANTS Fusobacterium canifelinum Fusobacterium equinum Fusobacterium gonidiaformans Fusobacterium hwasookii Fusobacterium mortiferum Fusobacterium naviforme Fusobacterium necrogenes Fusobacterium necrophorum Fusobacterium nucleatum Fusobacterium perfoetens Fusobacterium periodonticum Fusobacterium russii Fusobacterium simiae Fusobacterium sp. Fusobacterium sp. ACB2 Fusobacterium sp. AS2 Fusobacterium sp. CM1 Fusobacterium sp. CM21 Fusobacterium sp. CM22 Fusobacterium sp. CM55 Fusobacterium sp. DJF_B100 Fusobacterium sp. OBRC1 Fusobacterium sp. oral taxon 203 Fusobacterium sp. oral taxon 205 Fusobacterium sp. oral taxon 370 Fusobacterium ulcerans Fusobacterium varium environmental samples	INTERACTIONS	KEGG PATHWAYS 2-Oxocarboxylic acid metabolism ABC transporters Alanine, aspartate and glutamate metabolism Amino sugar and nucleotide sugar metabolism Aminoacyl-tRNA biosynthesis Aminobenzoate degradation Arachidonic acid metabolism Arginine and proline metabolism Arginine biosynthesis Bacterial chemotaxis Bacterial secretion system Base excision repair Benzoate degradation Biosynthesis of amino acids Biosynthesis of antibiotics Biosynthesis of secondary metabolites Biosynthesis of unsaturated fatty acids Biotin metabolism Butanoate metabolism Carbon metabolism Cationic antimicrobial peptide (CAMP) resistance Citrate cycle (TCA cycle) Cyanoamino acid metabolism Cysteine and methionine metabolism D-Alanine metabolism D-Glutamine and D-glutamate metabolism DNA replication Fatty acid biosynthesis Fatty acid degradation Fatty acid metabolism Folate biosynthesis Fructose and mannose metabolism Galactose metabolism Glutathione metabolism Glycerolipid metabolism Glycerophospholipid metabolism Glycine, serine and threonine metabolism Glycolysis / Gluconeogenesis Glyoxylate and dicarboxylate metabolism Histidine metabolism Homologous recombination Lipopolysaccharide biosynthesis Lysine biosynthesis Lysine degradation Metabolic pathways Methane metabolism Microbial metabolism in diverse environments Mismatch repair Nicotinate and nicotinamide metabolism Nitrogen metabolism Nucleotide excision repair One carbon pool by folate Oxidative phosphorylation Pantothenate and CoA biosynthesis Pentose and glucuronate interconversions Pentose phosphate pathway Peptidoglycan biosynthesis Phenylalanine metabolism Phenylalanine, tyrosine and tryptophan biosynthesis Phosphotransferase system (PTS) Polyketide sugar unit biosynthesis Porphyrin and chlorophyll metabolism Propanoate metabolism Protein export Purine metabolism Pyrimidine metabolism Pyruvate metabolism Quorum sensing00253 RNA degradation RNA polymerase Riboflavin metabolism Ribosome Selenocompound metabolism Starch and sucrose metabolism Streptomycin biosynthesis Styrene degradation Sulfur metabolism Sulfur relay system Taurine and hypotaurine metabolism Terpenoid backbone biosynthesis Thiamine metabolism Tryptophan metabolism Two-component system Tyrosine metabolism Ubiquinone and other terpenoid-quinone biosynthesis Valine, leucine and isoleucine degradation Vancomycin resistance Vitamin B6 metabolism beta-Lactam resistance CLUSTERS WITH	METABOLOMICS NUTRIENTS/ SUBSTRATES ENDPRODUCTS Biotin Propionate Lactate Succinate Butyrate Formate INHIBITED BY ENHANCED BY High fat diet BIOTRANSFORMS BIOTRANFORM
ANTIBIOTIC RESISTANCE Macrolide (mefa)	BIOFILM FORMERS Fusobacterium mortiferum Fusobacterium nucleatum Fusobacterium gonidiaformans	COGEM PATHOGENICITY Fusobacterium varium (2) Fusobacterium ulcerans (2) Fusobacterium russii (2) Fusobacterium necrophorum (2) Fusobacterium mortiferum (2) Fusobacterium nucleatum (2) Fusobacterium gonidiaformans (2) Fusobacterium periodonticum (2)

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