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Treponema lecithinolyticumRANK: SpeciesTAXONOMY: Bacteria -> Spirochaetes -> Spirochaetia -> Spirochaetales -> Spirochaetaceae -> Treponema -> Treponema lecithinolyticum OVERVIEW: Member of one of the 10 phylogenetic groups of oral treponemes [1,4]. Originally detected in subjects with periodontitis as not-yet-cultivated phylotype (Group IV) termed Treponema sp. IV:17C:GF6 [4]. Closest cultivable relative is Treponema maltophilum, which also falls in Group IV.Growth on OMIZ-Pat-w/oPC agarose [1], are off-white, diffuse (~3 mm), subsurface colonies after 7 days incubation at 37oC. Will not grow in chemically defined media, e.g., OMIZ-W1 [1], but requires yeast extract or Neopeptone Detected in human subgingival plaque, most often in subjects with periodontitisAssociation (e.g. diseased vs control sites) in patients with adult periodontitis and rapidly progressive periodontitis [1,3] and endodontic lesions [2]. Strong activities of phospholipase A and phospholipase C may serve as potential virulence factors [1]Identified as a constituent of the oral microbiome by Human Oral Microbiome Database. |