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Slackia isoflavoniconvertensRANK: SpeciesTAXONOMY: Terrabacteria group -> Actinobacteria -> Coriobacteriia -> Eggerthellales -> Eggerthellaceae -> Slackia -> Slackia isoflavoniconvertens OVERVIEW: A strain of Slackia isoflavoniconvertens detected among human colonic bacteria capable of metabolizing isoflavones converts daidzein to equol via the intermediate dihydrodaidzein ; the author showed that it transformed 80 µM of daidzein to equol in 10 h under anaerobic conditions. This bacterium also converts genistein to dihydrogenistein, which is then partially transformed to 5-hydroxyequol. Schröder et al., using daidzein-induced cultures of S. isoflavoniconvertens, identified the proteins involved in daidzein metabolism. They concluded that daidzein reductase converted daidzein and genistein to dihydrodaidzein and dpihydrogenistein; and recombinant dihydrodaidzein reductase and tetrahydrodaidzein reductase reduce dihydrodaidzein to equol]. [PMC:4381290] This species has been identified as a resident in the human gastrointestinal tract based on the phylogenetic framework of its small subunit ribosomal RNA gene sequences.[PMC 4262072] |