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Clostridium clostridioformeRANK: SpeciesTAXONOMY: Terrabacteria group -> Firmicutes -> Clostridia -> Clostridiales -> Lachnospiraceae -> Lachnoclostridium -> Clostridium clostridioforme OVERVIEW: 'Clostridium clostridioforme' is an anaerobic, motile, gram-positive bacterium. High Clostridium clostridioforme which is associated with diabetes, low gut diversity, inflammatory conditions and human invasive and severe infections like bacteremia. Often it produces alcohol and other toxins, which are associated with inflammation, artery hardening, and histamine responses. Alcohol from microbial fermentation results in blockages of multiple enzyme pathways in the host including the degradation of histamine. When more histamine accumulates, subsequently, the host has more allergic reactions, congestion, rash, headaches or other manifestations of high histamine. These are all secondary to a dysbiotic and imbalanced gut. This species has been identified as a resident in the human gastrointestinal tract based on the phylogenetic framework of its small subunit ribosomal RNA gene sequences.[PMC 4262072] |