Gynostemma Pentaphyllum is a plant which is sometimes referred to as either 'Southern Ginseng' or 'Cheap Ginseng' as it was used as a cheap substitute for Panax ginseng (as aside from Codonopsis pilosula, which was used as an adulterant for Panax Ginseng to sell it at the normal price but cut costs). Surprisingly, Gynostemma has a good content of Ginsenosides that were once thought to be wholly unique to Panax Ginseng. As such, the biological effects of Gynostemma and Panax seem to be quite similar except Gynostemma may be more anti-diabetic (due to the unique Gypenosides in Gynostemma, that are not in Panax). Gynostemma Pentaphyllum is best known as an herbal medicine reputed to have powerful antioxidant and adaptogenic effects purported to increase longevity. Pharmacological research has indicated a number of therapeutic qualities of jiaogulan, such as lowering cholesterol and high blood pressure, and strengthening immunity. Triterpenoid saponins isolated from Gynostemma pentaphyllum have significant effects on the gut microbiome and have been shown to module expression of E and N cadherin, beta_catenin, STAT3 and IL4.