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Oxalobacter formigenes

RANK: Species

TAXONOMY: Bacteria -> Proteobacteria -> Betaproteobacteria -> Burkholderiales -> Oxalobacteraceae -> Oxalobacter -> Oxalobacter formigenes

OVERVIEW:

'Oxalobacter formigenes' is an oxalate-degrading anaerobic bacterium that colonizes the large intestine of numerous vertebrates, including humans. O. formigenes and humans share a beneficial symbiosis. Quinolone, a broad-spectrum antibiotic, kills O. formigenes. If a person's gastrointestinal tract lacks this bacterium, and therefore lacks the primary source for the Oxalyl-CoA decarboxylase enzyme, then the GI tract cannot degrade dietary oxalates which on digestion get absorbed easily and after some Vit B6 modulated partial metabolical degradation in the body, is excreted in the kidney where it precipitates with calcium forming calcium oxalate kidney stones.[http://www.urologystone.com/CH18WhatsNew/2001AUA.html (interim reference, describes two other studies)] Synonyms : strain OxB, CIP 106513, ATCC 35274 Direct sub-taxa of Oxalobacter formigenes: Oxalobacter formigenes DSM 4420, Oxalobacter formigenes HOxBLS, Oxalobacter formigenes OXCC13

This species has been identified as a resident in the human gastrointestinal tract based on the phylogenetic framework of its small subunit ribosomal RNA gene sequences.[PMC 4262072]

COGEM

COGEM released a comprehensive database of pathogenicity assessment of around 2575 bacterial species in 2011. The database ranks the pathogenicity of species on a scale of 1 to 4. Oxalobacter formigenes ranks on this scale:

TAGS >

Keystone	Core species	Type species	Pathogen	Dysbiosis associated	Flora/ commensal	Gut associated	Probiotic
Leanness	Obesity	Skin microbiome	Fecal distribution	Oral microbiome	Vaginal microbiome	Butyrate producer	Catalase producer
Histamine producer	Food fermenter	Amylolytic	Propionate producer	Nitrifying	Biofilm producer

INTERACTIONS ENHANCES Bacteroidales Bacteroides Odoribacter Peptococcaceae INHIBITS Bifidobacterium Coriobacteriales Adlercreutzia Collinsella Porphyromonas Prevotella Clostridium Clostridiales incertae sedis Clostridiales Family XIII. Incertae Sedis Blautia Coprococcus Dorea Lachnospiraceae Ruminococcaceae Ruminococcus Dialister Campylobacteraceae Erysipelotrichaceae	KEGG PATHWAYS CLUSTERS WITH	METABOLOMICS NUTRIENTS/ SUBSTRATES Oxamate [parent] Acetate [parent] Oxalate [parent] ENDPRODUCTS Formate [parent] INHIBITED BY Doxycycline [parent] Tetracycline [parent] Erythromycin [parent] Chloramphenicol [parent] ENHANCED BY Vitamin C [parent] Magnesium [parent] Calcium [parent] BIOTRANSFORMS Oxalate [parent] BIOTRANFORM Formyl-CoA [parent]
ANTIBIOTIC RESISTANCE See Parent Genus (Oxalobacter)	BIOFILM FORMERS See Parent Genus (Oxalobacter)	COGEM PATHOGENICITY See Parent Genus (Oxalobacter)