Datapunk Opus23 | Coprococcus

Coprococcus

RANK: Genus

TAXONOMY: Bacteria -> Terrabacteria group -> Firmicutes -> Clostridia -> Clostridiales -> Lachnospiraceae -> Coprococcus

OVERVIEW:

'Coprococcus' is a genus of anaerobic cocci which are part of the human fecal flora. Cocci that are Gram-stain-positive, nonmotile, and obligately anaerobic chemoorganotrophs. All species in the genus are isolated from human feces (Moore and Holdeman, 1974) but rarely isolated from human clinical specimens. Strains were originally isolated on an anaerobically sterilized rumen-fluid-glucose-cellobiose agar (Holdeman et al., 1977a) roll tube. However, pure cultured strains grow on anaerobically incubated blood agar plates (supplemented with brain heart infusion agar with 5% sheep blood). Cells may occur as pairs or chains of pairs. Cells of the some species are slightly elongated, in particular, when grown in medium containing fermentable carbohydrates. Fermentable carbohydrates are either required or are highly stimulatory for growth. Major fermentation products include butyric and acetic acids, with formic or propionic acid. Characteristics to differentiate species of the genus Coprococcus and biochemically closely related species of the Ruminococcus are given in Table 167. The genus phylogenetically belongs to family Lachnospiraceae and the phylogenetic position within the family is shown in Figure 1 (Ezaki et al., 1994; Rainey and Janssen, 1995; Willems and Collins, 1995a). In the family Lachnospiraceae, members of genus Coprococcus are phylogenetically closely related to anaerobic curved bacteria, genus Lachnospira

This genus contains microbial species that can reside in the human gastrointestinal tract. [PMC 4262072] A new study of two large groups of Europeans, led by Dr. Sara Vieira-Silva and Dr. Jeroen Raes from the Catholic University of Leuven (Belgium), has found new links between gut microbes and depression. Dialister and Coprococcus genera were reduced in people with depression. [Nat Microbiol. 2019. doi: 10.1038/s41564-018-0337-x]

Microbial Abundance Data: Coprococcus (Percent of total population with standard deviation [PMID: 22698087])
Group 1				Group 2					Group 3			Group 4
Group 1 Avg	Buccal Mucosa	Keratinized Gingiva	Hard Palate	Group 2 Avg	Throat	Throat	Tonsils	Saliva	Group 3 Avg	Supragingival Plaque	Subgingival Plaque	Stool
0.005 % (0.023)	0.005 % (0.024)	0.001 % (0.006)	0.010 % (0.039)	0.005 % (0.026)	0.007 % (0.021)	0.003 % (0.031)	0.001 % (0.005)	0.008 % (0.048)	0.001 % (0.007)	0.000 % (0.001)	0.002 % (0.013)	0.829 % (1.098)

TAGS

Keystone	Core species	Type species	Pathogen	Dysbiosis associated	Flora/ commensal	Gut associated	Probiotic
Leanness	Obesity	Skin microbiome	Fecal distribution	Oral microbiome	Vaginal microbiome	Butyrate producer	Catalase producer
Histamine producer	Food fermenter	Amylolytic	Propionate producer	Nitrifying

DESCENDANTS Coprococcus catus Coprococcus comes Coprococcus eutactus Coprococcus sp. DJF_CR49 environmental samples	INTERACTIONS ENHANCES Bacteroidales Bacteroides Odoribacter Peptococcaceae Bacteroidales Bacteroides Odoribacter Peptococcaceae Bacteroidales Bacteroides Odoribacter Peptococcaceae Bacteroidales Bacteroides Odoribacter Peptococcaceae INHIBITS Bifidobacterium Coriobacteriales Adlercreutzia Collinsella Porphyromonas Prevotella Clostridium Clostridiales incertae sedis Clostridiales Family XIII. Incertae Sedis Blautia Coprococcus Dorea Lachnospiraceae Ruminococcaceae Ruminococcus Dialister Campylobacteraceae Erysipelotrichaceae Bifidobacterium Coriobacteriales Adlercreutzia Collinsella Porphyromonas Prevotella Clostridium Clostridiales incertae sedis Clostridiales Family XIII. Incertae Sedis Blautia Coprococcus Dorea Lachnospiraceae Ruminococcaceae Ruminococcus Dialister Campylobacteraceae Erysipelotrichaceae Bifidobacterium Coriobacteriales Adlercreutzia Collinsella Porphyromonas Prevotella Clostridium Clostridiales incertae sedis Clostridiales Family XIII. Incertae Sedis Blautia Coprococcus Dorea Lachnospiraceae Ruminococcaceae Ruminococcus Dialister Campylobacteraceae Erysipelotrichaceae Bifidobacterium Coriobacteriales Adlercreutzia Collinsella Porphyromonas Prevotella Clostridium Clostridiales incertae sedis Clostridiales Family XIII. Incertae Sedis Blautia Coprococcus Dorea Lachnospiraceae Ruminococcaceae Ruminococcus Dialister Campylobacteraceae Erysipelotrichaceae INHIBITED BY Bifidobacterium Bifidobacterium Coriobacteriales Coriobacteriales Adlercreutzia Adlercreutzia Collinsella Collinsella Bacteroidales Bacteroidales Bacteroides Bacteroides Porphyromonadaceae Porphyromonadaceae Odoribacter Odoribacter Parabacteroides Parabacteroides Porphyromonas Porphyromonas Prevotella Prevotella Rikenellaceae Rikenellaceae Alistipes Alistipes Turicibacter Turicibacter Streptococcus Streptococcus Clostridiales Clostridiales Catabacteriaceae Catabacteriaceae Clostridium Clostridium Clostridiales incertae sedis Clostridiales incertae sedis Peptoniphilus Peptoniphilus Clostridiales Family XIII. Incertae Sedis Clostridiales Family XIII. Incertae Sedis Lachnospiraceae Lachnospiraceae Blautia Blautia Lachnospiraceae Lachnospiraceae Coprococcus Coprococcus Dorea Dorea Eubacterium Eubacterium Lachnobacterium Lachnobacterium Lachnospira Lachnospira Roseburia Roseburia Lachnospiraceae Lachnospiraceae Peptococcaceae Peptococcaceae Ruminococcaceae Ruminococcaceae Ruminiclostridium Ruminiclostridium Acetivibrio Acetivibrio Eubacterium Eubacterium Faecalibacterium Faecalibacterium Oscillospira Oscillospira Ruminococcus Ruminococcus Acidaminococcus Acidaminococcus Dialister Dialister Phascolarctobacterium Phascolarctobacterium Veillonella Veillonella Rubrivivax Rubrivivax Alcaligenaceae Alcaligenaceae Oxalobacter Oxalobacter Bilophila Bilophila Desulfovibrio Desulfovibrio Campylobacteraceae Campylobacteraceae Enterobacteriaceae Enterobacteriaceae Escherichia Escherichia Erysipelotrichaceae Erysipelotrichaceae Erysipelotrichaceae Erysipelotrichaceae Holdemania Holdemania Akkermansia Akkermansia	KEGG PATHWAYS 2-Oxocarboxylic acid metabolism ABC transporters Alanine, aspartate and glutamate metabolism Amino sugar and nucleotide sugar metabolism Aminoacyl-tRNA biosynthesis Arginine and proline metabolism Arginine biosynthesis Ascorbate and aldarate metabolism Bacterial secretion system Base excision repair Benzoate degradation Biosynthesis of amino acids Biosynthesis of antibiotics Biosynthesis of secondary metabolites Biosynthesis of unsaturated fatty acids Biotin metabolism Butanoate metabolism C5-Branched dibasic acid metabolism Carbapenem biosynthesis Carbon metabolism Cationic antimicrobial peptide (CAMP) resistance Chloroalkane and chloroalkene degradation Citrate cycle (TCA cycle) Cyanoamino acid metabolism Cysteine and methionine metabolism D-Alanine metabolism DNA replication Degradation of aromatic compounds Fatty acid biosynthesis Fatty acid degradation Fatty acid metabolism Folate biosynthesis Fructose and mannose metabolism Galactose metabolism Glutathione metabolism Glycerolipid metabolism Glycerophospholipid metabolism Glycine, serine and threonine metabolism Glycolysis / Gluconeogenesis Glyoxylate and dicarboxylate metabolism Histidine metabolism Homologous recombination Inositol phosphate metabolism Insulin resistance Limonene and pinene degradation Lysine biosynthesis Lysine degradation Metabolic pathways Methane metabolism Microbial metabolism in diverse environments Mismatch repair Monobactam biosynthesis Naphthalene degradation Nicotinate and nicotinamide metabolism Nitrogen metabolism Novobiocin biosynthesis Nucleotide excision repair One carbon pool by folate Other glycan degradation Oxidative phosphorylation Pantothenate and CoA biosynthesis Pentose and glucuronate interconversions Pentose phosphate pathway Peptidoglycan biosynthesis Phenylalanine metabolism Phenylalanine, tyrosine and tryptophan biosynthesis Phosphotransferase system (PTS) Polyketide sugar unit biosynthesis Porphyrin and chlorophyll metabolism Propanoate metabolism Protein export Purine metabolism Pyrimidine metabolism Pyruvate metabolism RNA degradation RNA polymerase Riboflavin metabolism Ribosome Secondary bile acid biosynthesis Selenocompound metabolism Starch and sucrose metabolism Streptomycin biosynthesis Sulfur metabolism Sulfur relay system Taurine and hypotaurine metabolism Terpenoid backbone biosynthesis Thiamine metabolism Tryptophan metabolism Two-component system Tyrosine metabolism Valine, leucine and isoleucine biosynthesis Valine, leucine and isoleucine degradation Vancomycin resistance Vitamin B6 metabolism beta-Alanine metabolism beta-Lactam resistance CLUSTERS WITH	METABOLOMICS NUTRIENTS/ SUBSTRATES ENDPRODUCTS Butyrate [parent] Butyrate Acetate INHIBITED BY Flaxseed [parent] High fat diet Quercetin w. Resveratrol [parent] Polymannuronic acid ENHANCED BY Chemotherapy Walnuts [parent] Walnuts Saccharomyces boulardii [parent] Resistant starch (type II) BIOTRANSFORMS Linoleic acid (LA) [parent] Linolenic acid (CLnA) [parent] Trimethylamine [parent] BIOTRANFORM Trimethylamine-N-oxide (TMAO) [parent] Trans-11 conjugate linoleic acid (CLA) [parent] Cis-9 conjugate linoleic acid (CLA) [parent] Cis-15 conjugate linolenic acids (CLnA) [parent] Cis-9 conjugate linolenic acids (CLnA) [parent] Trans-11 conjugate linolenic acids (CLnA) [parent]
ANTIBIOTIC RESISTANCE	BIOFILM FORMERS Coprococcus eutactus	COGEM PATHOGENICITY

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