Datapunk Opus23 | Blautia

Blautia

RANK: Genus

TAXONOMY: Bacteria -> Terrabacteria group -> Firmicutes -> Clostridia -> Clostridiales -> Lachnospiraceae -> Blautia

OVERVIEW:

Blautia may assist in the digestion of complex carbohydrates. An abundance of these bacteria is a strong indication of a healthy gut. Blautia levels are increased in healthy people when compared to patients with liver disease and colorectal cancer and children with diabetes. The relationship between intestinal microbiota composition and acute graft-versus-host disease (GVHD) after allogeneic blood/marrow transplantation (allo-BMT) is not well understood. Intestinal bacteria have long been thought to contribute to GVHD pathophysiology, but recent animal studies in nontransplant settings have found that anti-inflammatory effects are mediated by certain subpopulations of intestinal commensals. Hypothesizing that a more nuanced relationship may exist between the intestinal bacteria and GVHD, we evaluated the fecal bacterial composition of 64 patients 12 days after BMT. We found that increased bacterial diversity was associated with reduced GVHD-related mortality. Furthermore, harboring increased amounts of bacteria belonging to the genus Blautia was associated with reduced GVHD lethality in this cohort and was confirmed in another independent cohort of 51 patients from the same institution. Blautia abundance was also associated with improved overall survival. We evaluated the abundance of Blautia with respect to clinical factors and found that loss of Blautia was associated with treatment with antibiotics that inhibit anaerobic bacteria and receiving total parenteral nutrition for longer durations. We conclude that increased abundance of commensal bacteria belonging to the Blautia genus is associated with reduced lethal GVHD and improved overall survival. PMID: 25977230

This genus contains microbial species that can reside in the human gastrointestinal tract. [PMC 4262072]

Specific differences have been found in blood group A-secretors demonstrating that the genus Blautia is lower in the group A-secretors compared with the non-A-secretors. [PMCID: PMC5625272]

Microbial Abundance Data: Blautia (Percent of total population with standard deviation [PMID: 22698087])
Group 1				Group 2					Group 3			Group 4
Group 1 Avg	Buccal Mucosa	Keratinized Gingiva	Hard Palate	Group 2 Avg	Throat	Throat	Tonsils	Saliva	Group 3 Avg	Supragingival Plaque	Subgingival Plaque	Stool
0.005 % (0.023)	0.004 % (0.014)	0.001 % (0.006)	0.010 % (0.049)	0.004 % (0.017)	0.008 % (0.027)	0.003 % (0.022)	0.001 % (0.007)	0.004 % (0.013)	0.001 % (0.011)	0.000 % (0.000)	0.002 % (0.023)	0.765 % (0.956)

TAGS

Keystone	Core species	Type species	Pathogen	Dysbiosis associated	Flora/ commensal	Gut associated	Probiotic
Leanness	Obesity	Skin microbiome	Fecal distribution	Oral microbiome	Vaginal microbiome	Butyrate producer	Catalase producer
Histamine producer	Food fermenter	Amylolytic	Propionate producer	Nitrifying

DESCENDANTS Blautia coccoides Blautia faecis Blautia glucerasea Blautia hansenii Blautia hydrogenotrophica Blautia luti Blautia obeum Blautia producta Blautia schinkii Blautia sp. Ser5 Blautia sp. Ser8 Blautia sp. YHC-4 Blautia stercoris Blautia wexlerae Ruminococcus gnavus Ruminococcus torques environmental samples	INTERACTIONS ENHANCES Bacteroidales Bacteroides Odoribacter Peptococcaceae Bacteroidales Bacteroides Odoribacter Peptococcaceae Bacteroidales Bacteroides Odoribacter Peptococcaceae Bacteroidales Bacteroides Odoribacter Peptococcaceae INHIBITS Peptoclostridium Bifidobacterium Coriobacteriales Adlercreutzia Collinsella Porphyromonas Prevotella Clostridium Clostridiales incertae sedis Clostridiales Family XIII. Incertae Sedis Blautia Coprococcus Dorea Lachnospiraceae Ruminococcaceae Ruminococcus Dialister Campylobacteraceae Erysipelotrichaceae Bifidobacterium Coriobacteriales Adlercreutzia Collinsella Porphyromonas Prevotella Clostridium Clostridiales incertae sedis Clostridiales Family XIII. Incertae Sedis Blautia Coprococcus Dorea Lachnospiraceae Ruminococcaceae Ruminococcus Dialister Campylobacteraceae Erysipelotrichaceae Bifidobacterium Coriobacteriales Adlercreutzia Collinsella Porphyromonas Prevotella Clostridium Clostridiales incertae sedis Clostridiales Family XIII. Incertae Sedis Blautia Coprococcus Dorea Lachnospiraceae Ruminococcaceae Ruminococcus Dialister Campylobacteraceae Erysipelotrichaceae Bifidobacterium Coriobacteriales Adlercreutzia Collinsella Porphyromonas Prevotella Clostridium Clostridiales incertae sedis Clostridiales Family XIII. Incertae Sedis Blautia Coprococcus Dorea Lachnospiraceae Ruminococcaceae Ruminococcus Dialister Campylobacteraceae Erysipelotrichaceae INHIBITED BY Bifidobacterium Bifidobacterium Coriobacteriales Coriobacteriales Adlercreutzia Adlercreutzia Collinsella Collinsella Bacteroidales Bacteroidales Bacteroides Bacteroides Porphyromonadaceae Porphyromonadaceae Odoribacter Odoribacter Parabacteroides Parabacteroides Porphyromonas Porphyromonas Prevotella Prevotella Rikenellaceae Rikenellaceae Alistipes Alistipes Turicibacter Turicibacter Streptococcus Streptococcus Clostridiales Clostridiales Catabacteriaceae Catabacteriaceae Clostridium Clostridium Clostridiales incertae sedis Clostridiales incertae sedis Peptoniphilus Peptoniphilus Clostridiales Family XIII. Incertae Sedis Clostridiales Family XIII. Incertae Sedis Lachnospiraceae Lachnospiraceae Blautia Blautia Lachnospiraceae Lachnospiraceae Coprococcus Coprococcus Dorea Dorea Eubacterium Eubacterium Lachnobacterium Lachnobacterium Lachnospira Lachnospira Roseburia Roseburia Lachnospiraceae Lachnospiraceae Peptococcaceae Peptococcaceae Ruminococcaceae Ruminococcaceae Ruminiclostridium Ruminiclostridium Acetivibrio Acetivibrio Eubacterium Eubacterium Faecalibacterium Faecalibacterium Oscillospira Oscillospira Ruminococcus Ruminococcus Acidaminococcus Acidaminococcus Dialister Dialister Phascolarctobacterium Phascolarctobacterium Veillonella Veillonella Rubrivivax Rubrivivax Alcaligenaceae Alcaligenaceae Oxalobacter Oxalobacter Bilophila Bilophila Desulfovibrio Desulfovibrio Campylobacteraceae Campylobacteraceae Enterobacteriaceae Enterobacteriaceae Escherichia Escherichia Erysipelotrichaceae Erysipelotrichaceae Erysipelotrichaceae Erysipelotrichaceae Holdemania Holdemania Akkermansia Akkermansia	KEGG PATHWAYS 2-Oxocarboxylic acid metabolism ABC transporters Alanine, aspartate and glutamate metabolism Amino sugar and nucleotide sugar metabolism Aminoacyl-tRNA biosynthesis Arginine and proline metabolism Arginine biosynthesis Ascorbate and aldarate metabolism Bacterial chemotaxis Bacterial secretion system Base excision repair Benzoate degradation Biosynthesis of amino acids Biosynthesis of antibiotics Biosynthesis of secondary metabolites Biosynthesis of siderophore group nonribosomal peptides Biosynthesis of unsaturated fatty acids Biotin metabolism Butanoate metabolism C5-Branched dibasic acid metabolism Carbapenem biosynthesis Carbon metabolism Cationic antimicrobial peptide (CAMP) resistance Chloroalkane and chloroalkene degradation Citrate cycle (TCA cycle) Cyanoamino acid metabolism Cysteine and methionine metabolism D-Alanine metabolism D-Glutamine and D-glutamate metabolism DNA replication Degradation of aromatic compounds Fatty acid biosynthesis Fatty acid degradation Fatty acid metabolism Folate biosynthesis Fructose and mannose metabolism Galactose metabolism Glutathione metabolism Glycerolipid metabolism Glycerophospholipid metabolism Glycine, serine and threonine metabolism Glycolysis / Gluconeogenesis Glyoxylate and dicarboxylate metabolism Histidine metabolism Homologous recombination Inositol phosphate metabolism Insulin resistance Lysine biosynthesis Lysine degradation Metabolic pathways Methane metabolism Microbial metabolism in diverse environments Mismatch repair Monobactam biosynthesis Naphthalene degradation Nicotinate and nicotinamide metabolism Nitrogen metabolism Novobiocin biosynthesis Nucleotide excision repair One carbon pool by folate Other glycan degradation Oxidative phosphorylation Pantothenate and CoA biosynthesis Pentose and glucuronate interconversions Pentose phosphate pathway Peptidoglycan biosynthesis Phenylalanine metabolism Phenylalanine, tyrosine and tryptophan biosynthesis Phosphotransferase system (PTS) Polyketide sugar unit biosynthesis Porphyrin and chlorophyll metabolism Propanoate metabolism Protein export Purine metabolism Pyrimidine metabolism Pyruvate metabolism RNA degradation RNA polymerase Riboflavin metabolism Ribosome Secondary bile acid biosynthesis Selenocompound metabolism Sphingolipid metabolism Starch and sucrose metabolism Streptomycin biosynthesis Sulfur metabolism Sulfur relay system Taurine and hypotaurine metabolism Terpenoid backbone biosynthesis Thiamine metabolism Tryptophan metabolism Two-component system Tyrosine metabolism Valine, leucine and isoleucine biosynthesis Valine, leucine and isoleucine degradation Vancomycin resistance Vitamin B6 metabolism beta-Alanine metabolism beta-Lactam resistance CLUSTERS WITH	METABOLOMICS NUTRIENTS/ SUBSTRATES ENDPRODUCTS Butyrate [parent] INHIBITED BY Walnuts Flaxseed [parent] Quercetin w. Resveratrol [parent] ENHANCED BY Cholic acid Walnuts [parent] Resistant starch (type IV) Saccharomyces boulardii [parent] Resistant starch (type II) Berberine BIOTRANSFORMS Linoleic acid (LA) [parent] Linolenic acid (CLnA) [parent] Trimethylamine [parent] BIOTRANFORM Trimethylamine-N-oxide (TMAO) [parent] Trans-11 conjugate linoleic acid (CLA) [parent] Cis-9 conjugate linoleic acid (CLA) [parent] Cis-15 conjugate linolenic acids (CLnA) [parent] Cis-9 conjugate linolenic acids (CLnA) [parent] Trans-11 conjugate linolenic acids (CLnA) [parent]
ANTIBIOTIC RESISTANCE	BIOFILM FORMERS	COGEM PATHOGENICITY Blautia sp KLE 1732 (1) Ruminococcus obeum (1) Blautia producta (1)

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