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Alistipes

RANK: Genus

TAXONOMY: Bacteria -> Bacteroidetes/Chlorobi group -> Bacteroidetes -> Bacteroidia -> Bacteroidales -> Rikenellaceae -> Alistipes

OVERVIEW:

'Alistipes' is a genus in the phylum Bacteroidetes (Bacteria). Alistipes are bacteria commensal to the gut and, in limited quantities, are indicative of gastrointestinal good-health. However, these microbes shun diets rich in plant-based foods, thrive on high-fat diets, and grow especially well in the gut microbiomes of those suffering from obesity. Fortunately, the bugs all but vanish after a course of antibiotics, so such treatment has potential as an anti-obesity therapeutic. Straight or slightly curved rods 0.2–0.9 µm in diameter × 0.5–4 µm in length, with rounded ends. Swellings may occur, but spores are not formed. Cells usually occur singly or in pairs, occasionally in longer filaments. Nonmotile. Gram negative. Obligately anaerobic. Indole is produced. Gelatin is digested. Nitrate is not reduced to nitrite. Arginine and urea are not hydrolyzed. Produce succinic acid as the major glucose metabolic end product, with minor amounts of acetic acid. The major long-chain fatty acid produced is C15:0 iso.

DNA G+C content (mol%): 55–58.

This genus contains microbial species that can reside in the human gastrointestinal tract. [PMC 4262072]

Microbial Abundance Data: Alistipes (Percent of total population with standard deviation [PMID: 22698087])
Group 1				Group 2					Group 3			Group 4
Group 1 Avg	Buccal Mucosa	Keratinized Gingiva	Hard Palate	Group 2 Avg	Throat	Throat	Tonsils	Saliva	Group 3 Avg	Supragingival Plaque	Subgingival Plaque	Stool
0.014 % (0.068)	0.009 % (0.028)	0.007 % (0.065)	0.027 % (0.110)	0.013 % (0.071)	0.026 % (0.185)	0.006 % (0.036)	0.001 % (0.003)	0.018 % (0.061)	0.005 % (0.041)	0.001 % (0.004)	0.009 % (0.079)	5.511 % (6.234)

TAGS

Keystone	Core species	Type species	Pathogen	Dysbiosis associated	Flora/ commensal	Gut associated	Probiotic
Leanness	Obesity	Skin microbiome	Fecal distribution	Oral microbiome	Vaginal microbiome	Butyrate producer	Catalase producer
Histamine producer	Food fermenter	Amylolytic	Propionate producer	Nitrifying

DESCENDANTS Alistipes finegoldii Alistipes indistinctus Alistipes inops Alistipes massiliensis Alistipes obesi Alistipes onderdonkii Alistipes putredinis Alistipes senegalensis Alistipes shahii Alistipes sp. EBA6-25cl2 Alistipes sp. HGB5 Alistipes sp. NML05A004 Alistipes sp. RMA 9912 Alistipes timonensis Candidatus Alistipes marseilloanorexicus environmental samples	INTERACTIONS ENHANCES Bacteroidales Bacteroides Odoribacter Peptococcaceae Bacteroidales Bacteroides Odoribacter Peptococcaceae INHIBITS Bifidobacterium Coriobacteriales Adlercreutzia Collinsella Porphyromonas Prevotella Clostridium Clostridiales incertae sedis Clostridiales Family XIII. Incertae Sedis Blautia Coprococcus Dorea Lachnospiraceae Ruminococcaceae Ruminococcus Dialister Campylobacteraceae Erysipelotrichaceae Bifidobacterium Coriobacteriales Adlercreutzia Collinsella Porphyromonas Prevotella Clostridium Clostridiales incertae sedis Clostridiales Family XIII. Incertae Sedis Blautia Coprococcus Dorea Lachnospiraceae Ruminococcaceae Ruminococcus Dialister Campylobacteraceae Erysipelotrichaceae INHIBITED BY Faecalibacterium	KEGG PATHWAYS 2-Oxocarboxylic acid metabolism ABC transporters Alanine, aspartate and glutamate metabolism Amino sugar and nucleotide sugar metabolism Aminoacyl-tRNA biosynthesis Arginine and proline metabolism Arginine biosynthesis Ascorbate and aldarate metabolism Bacterial secretion system Base excision repair Biosynthesis of amino acids Biosynthesis of antibiotics Biosynthesis of secondary metabolites Biosynthesis of unsaturated fatty acids Biotin metabolism Butanoate metabolism C5-Branched dibasic acid metabolism Carbapenem biosynthesis Carbon metabolism Cationic antimicrobial peptide (CAMP) resistance Chloroalkane and chloroalkene degradation Citrate cycle (TCA cycle) Cyanoamino acid metabolism Cysteine and methionine metabolism D-Glutamine and D-glutamate metabolism DNA replication Fatty acid biosynthesis Fatty acid degradation Fatty acid metabolism Folate biosynthesis Fructose and mannose metabolism Galactose metabolism Glutathione metabolism Glycerolipid metabolism Glycerophospholipid metabolism Glycine, serine and threonine metabolism Glycolysis / Gluconeogenesis Glyoxylate and dicarboxylate metabolism Histidine metabolism Homologous recombination Inositol phosphate metabolism Lipoic acid metabolism Lipopolysaccharide biosynthesis Lysine biosynthesis Lysine degradation Metabolic pathways Methane metabolism Microbial metabolism in diverse environments Mismatch repair Monobactam biosynthesis Nicotinate and nicotinamide metabolism Nitrogen metabolism Novobiocin biosynthesis Nucleotide excision repair One carbon pool by folate Other glycan degradation Oxidative phosphorylation Pantothenate and CoA biosynthesis Pentose and glucuronate interconversions Pentose phosphate pathway Peptidoglycan biosynthesis Phenylalanine, tyrosine and tryptophan biosynthesis Polyketide sugar unit biosynthesis Porphyrin and chlorophyll metabolism Propanoate metabolism Protein export Purine metabolism Pyrimidine metabolism Pyruvate metabolism RNA degradation RNA polymerase Riboflavin metabolism Ribosome Secondary bile acid biosynthesis Selenocompound metabolism Sphingolipid metabolism Starch and sucrose metabolism Streptomycin biosynthesis Sulfur metabolism Taurine and hypotaurine metabolism Terpenoid backbone biosynthesis Tryptophan metabolism Two-component system Ubiquinone and other terpenoid-quinone biosynthesis Valine, leucine and isoleucine biosynthesis Valine, leucine and isoleucine degradation Vancomycin resistance Vitamin B6 metabolism beta-Alanine metabolism beta-Lactam resistance CLUSTERS WITH	METABOLOMICS NUTRIENTS/ SUBSTRATES D-Glucose L-Tryptophan Thiamine ENDPRODUCTS Indole Acetic acid Succinic acid INHIBITED BY Plant-rich diet Tannin Cranberry bean flour Gallate Cranberry bean flour [parent] ENHANCED BY High fat diet High fruit intake High meat diet BIOTRANSFORMS BIOTRANFORM
ANTIBIOTIC RESISTANCE	BIOFILM FORMERS	COGEM PATHOGENICITY Alistipes putredinis (2) Alistipes shahii (2) Alistipes onderdonkii (1)