Datapunk Opus23 | Faecalibacterium

Faecalibacterium

RANK: Genus

TAXONOMY: Bacteria -> Terrabacteria group -> Firmicutes -> Clostridia -> Clostridiales -> Ruminococcaceae -> Faecalibacterium

OVERVIEW:

'Faecalibacterium' is a genus of bacteria. Its sole known species, 'Faecalibacterium prausnitzii', is an important commensal bacterium of the human gut flora. This bacteria is considered beneficial and is one of the most prevalent intestinal bacterial species in healthy adults. The reduction of this bacteria in the gut (as measured by analyzing bacteria in fecal samples) is seen in several diseases, including Intestinal Bowel Disease (IBD). This bacteria has also been found to be anti-inflammatory. Babies with a higher risk of asthma presented lower levels of four bacteria in their feces samples in comparison with the infants who did not show any symptoms. Those bacteria were identified as Faecalibacterium, Lachnospira, Veillonella and Rothia - known all together as FLVR. A high animal meat, high animal fat, high sugar, highly processed foods, and low fiber diet (the typical westernized diet) lowers F. prausnitzii numbers, while a high-fiber, low meat diet increases F. prausnitzii numbers.Scientists at Catholic University of Louvain in Belgium recently showed that adding inulin, a fermentable fiber, to the diet of obese women increased counts of F. prausnitzii and other clostridial bacteria.

This genus contains microbial species that can reside in the human gastrointestinal tract. [PMC 4262072] Decrease in metabolic disorders.

Microbial Abundance Data: Faecalibacterium (Percent of total population with standard deviation [PMID: 22698087])
Group 1				Group 2					Group 3			Group 4
Group 1 Avg	Buccal Mucosa	Keratinized Gingiva	Hard Palate	Group 2 Avg	Throat	Throat	Tonsils	Saliva	Group 3 Avg	Supragingival Plaque	Subgingival Plaque	Stool
0.015 % (0.073)	0.007 % (0.021)	0.003 % (0.013)	0.035 % (0.185)	0.012 % (0.065)	0.027 % (0.151)	0.011 % (0.071)	0.001 % (0.005)	0.009 % (0.032)	0.005 % (0.035)	0.000 % (0.003)	0.009 % (0.067)	4.580 % (5.185)

TAGS

Keystone	Core species	Type species	Pathogen	Dysbiosis associated	Flora/ commensal	Gut associated	Probiotic
Leanness	Obesity	Skin microbiome	Fecal distribution	Oral microbiome	Vaginal microbiome	Butyrate producer	Catalase producer
Histamine producer	Food fermenter	Amylolytic	Propionate producer	Nitrifying

DESCENDANTS Faecalibacterium prausnitzii Faecalibacterium sp. DJF_VR20 Faecalibacterium sp. canine oral taxon 147 environmental samples	INTERACTIONS ENHANCES Roseburia Anaerostipes Bacteroidales Bacteroides Odoribacter Peptococcaceae Bacteroidales Bacteroides Odoribacter Peptococcaceae INHIBITS Alistipes Bifidobacterium Coriobacteriales Adlercreutzia Collinsella Porphyromonas Prevotella Clostridium Clostridiales incertae sedis Clostridiales Family XIII. Incertae Sedis Blautia Coprococcus Dorea Lachnospiraceae Ruminococcaceae Ruminococcus Dialister Campylobacteraceae Erysipelotrichaceae Bifidobacterium Coriobacteriales Adlercreutzia Collinsella Porphyromonas Prevotella Clostridium Clostridiales incertae sedis Clostridiales Family XIII. Incertae Sedis Blautia Coprococcus Dorea Lachnospiraceae Ruminococcaceae Ruminococcus Dialister Campylobacteraceae Erysipelotrichaceae INHIBITED BY Bifidobacterium Coriobacteriales Adlercreutzia Collinsella Bacteroidales Bacteroides Porphyromonadaceae Odoribacter Parabacteroides Porphyromonas Prevotella Rikenellaceae Alistipes Turicibacter Streptococcus Clostridiales Catabacteriaceae Clostridium Clostridiales incertae sedis Peptoniphilus Clostridiales Family XIII. Incertae Sedis Lachnospiraceae Blautia Lachnospiraceae Coprococcus Dorea Eubacterium Lachnobacterium Lachnospira Roseburia Lachnospiraceae Peptococcaceae Ruminococcaceae Ruminiclostridium Acetivibrio Eubacterium Faecalibacterium Oscillospira Ruminococcus Acidaminococcus Dialister Phascolarctobacterium Veillonella Rubrivivax Alcaligenaceae Oxalobacter Bilophila Desulfovibrio Campylobacteraceae Enterobacteriaceae Escherichia Erysipelotrichaceae Erysipelotrichaceae Holdemania Akkermansia	KEGG PATHWAYS 2-Oxocarboxylic acid metabolism ABC transporters Alanine, aspartate and glutamate metabolism Amino sugar and nucleotide sugar metabolism Aminoacyl-tRNA biosynthesis Arginine and proline metabolism Arginine biosynthesis Bacterial secretion system Base excision repair Benzoate degradation Biosynthesis of amino acids Biosynthesis of antibiotics Biosynthesis of secondary metabolites Biosynthesis of unsaturated fatty acids Biotin metabolism Butanoate metabolism C5-Branched dibasic acid metabolism Carbapenem biosynthesis Carbon metabolism Citrate cycle (TCA cycle) Cyanoamino acid metabolism Cysteine and methionine metabolism D-Alanine metabolism D-Glutamine and D-glutamate metabolism DNA replication Fatty acid biosynthesis Fatty acid degradation Fatty acid metabolism Folate biosynthesis Fructose and mannose metabolism Galactose metabolism Glutathione metabolism Glycerolipid metabolism Glycerophospholipid metabolism Glycine, serine and threonine metabolism Glycolysis / Gluconeogenesis Glyoxylate and dicarboxylate metabolism Histidine metabolism Homologous recombination Inositol phosphate metabolism Insulin resistance Lysine biosynthesis Lysine degradation Metabolic pathways Methane metabolism Microbial metabolism in diverse environments Mismatch repair Monobactam biosynthesis Nicotinate and nicotinamide metabolism Nitrogen metabolism Novobiocin biosynthesis Nucleotide excision repair One carbon pool by folate Other glycan degradation Oxidative phosphorylation Pantothenate and CoA biosynthesis Pentose and glucuronate interconversions Pentose phosphate pathway Peptidoglycan biosynthesis Phenylalanine metabolism Phenylalanine, tyrosine and tryptophan biosynthesis Phosphotransferase system (PTS) Polyketide sugar unit biosynthesis Porphyrin and chlorophyll metabolism Propanoate metabolism Protein export Purine metabolism Pyrimidine metabolism Pyruvate metabolism RNA degradation RNA polymerase Riboflavin metabolism Ribosome Selenocompound metabolism Starch and sucrose metabolism Streptomycin biosynthesis Sulfur metabolism Sulfur relay system Synthesis and degradation of ketone bodies Taurine and hypotaurine metabolism Terpenoid backbone biosynthesis Thiamine metabolism Two-component system Valine, leucine and isoleucine biosynthesis Valine, leucine and isoleucine degradation Vancomycin resistance Vitamin B6 metabolism beta-Lactam resistance CLUSTERS WITH	METABOLOMICS NUTRIENTS/ SUBSTRATES Raffinose D-Glucose Galacturonic acid Riboflavin Arabinogalactan Stachyose (soy oligosaccharide) N-Acetyl-D-glucosamine Inulin Acetate Pectin ENDPRODUCTS D-lactate Butyrate Formate INHIBITED BY Chemotherapy High sugar diet High fat diet High animal protein diet Gallate [parent] Omega 3 fatty acids Fructo-oligosaccharides Bile salts Resistant starch (type IV) High animal fat diet Low fiber diet Low FODMAP diet Flaxseed High processed foods diet Navy bean (Cooked) ENHANCED BY Fasting Epinephrine Resistant starch (type III) Saccharomyces boulardii [parent] Quercetin w. Resveratrol [parent] Red wine Arabinogalactan Low processed foods diet High fiber diet Jerusalem artichoke Low animal protein diet Walnuts [parent] Chicory Inulin Dopamine Berberine [parent] BIOTRANSFORMS BIOTRANFORM
ANTIBIOTIC RESISTANCE Tetracycline (tetw)	BIOFILM FORMERS Faecalibacterium prausnitzii	COGEM PATHOGENICITY Faecalibacterium prausnitzii (2)

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