Roseburia intestinalis

RANK: Species

TAXONOMY: Terrabacteria group -> Firmicutes -> Clostridia -> Clostridiales -> Lachnospiraceae -> Roseburia -> Roseburia intestinalis

OVERVIEW:

Roseburia intestinalis is a saccharolytic, butyrate-producing bacterium first isolated from human feces. It is anaerobic, gram-positive, slightly curved rod-shaped and motile by means of multiple subterminal flagella. Roseburia favors and loves starches that escape small intestinal degradation and RS3, cooked-cooled starches. R. intestinalis works synergistically often with Bifidobacteria. Very low carbohydrate diets can cause Roseburia counts to drop, which can cause butyrate to drop as well. Chitin and beta-glucan encourage Roseburia. (as does low dose RS2, green banana flour or RPS). High dose RS2 however will decrease Roseburia (Tachon /2013). Lower concentrations in Type II diabetics.

This species has been identified as a resident in the human gastrointestinal tract based on the phylogenetic framework of its small subunit ribosomal RNA gene sequences.[PMC 4262072]

1

COGEM

COGEM released a comprehensive database of pathogenicity assessment of around 2575 bacterial species in 2011. The database ranks the pathogenicity of species on a scale of 1 to 4. Roseburia intestinalis ranks 1 on this scale: The species or strain does not belong to a recognized group of disease-invoking agents in humans or animals and/or has an extended history of safe usage under conditions without any physical restrictions

Identified as a 'core species' of the human gut microbiome. [PMID: 23222524]

TAGS

Keystone	Core species	Type species	Pathogen	Dysbiosis associated	Flora/ commensal	Gut associated	Probiotic
Leanness	Obesity	Skin microbiome	Fecal distribution	Oral microbiome	Vaginal microbiome	Butyrate producer	Catalase producer
Histamine producer	Food fermenter	Amylolytic	Propionate producer	Nitrifying	Biofilm producer

INTERACTIONS ENHANCES Bacteroidales Bacteroides Odoribacter Peptococcaceae INHIBITS Bifidobacterium Coriobacteriales Adlercreutzia Collinsella Porphyromonas Prevotella Clostridium Clostridiales incertae sedis Clostridiales Family XIII. Incertae Sedis Blautia Coprococcus Dorea Lachnospiraceae Ruminococcaceae Ruminococcus Dialister Campylobacteraceae Erysipelotrichaceae ENHANCED BY Bifidobacterium Faecalibacterium	KEGG PATHWAYS CLUSTERS WITH	METABOLOMICS NUTRIENTS/ SUBSTRATES Resistant starch (type II) [parent] N-Acetyl-D-glucosamine [parent] β-Glucan Resistant starch (type III) Acetate [parent] Resistant starch (type II) β-Glucan [parent] Chitin N-Acetyl-D-glucosamine Resistant starch (type III) [parent] Arabinoxylans [parent] Raffinose [parent] Stachyose (soy oligosaccharide) [parent] Chitin [parent] ENDPRODUCTS Lactate [parent] Butyrate [parent] Butyrate INHIBITED BY High animal protein diet [parent] Low carbohydrate diet [parent] Ketogenic diet [parent] High meat diet [parent] Epinephrine [parent] Fructo-oligosaccharides [parent] ENHANCED BY Resistant starch (type II) [parent] Almonds/ almond skins [parent] Polymannuronic acid [parent] Vitamin D [parent] N-Acetyl-D-glucosamine [parent] Dopamine [parent] β-Glucan [parent] Walnuts [parent] Arabinoxylans [parent] Dietary fiber [parent] BIOTRANSFORMS BIOTRANFORM
ANTIBIOTIC RESISTANCE See Parent Genus (Roseburia)	BIOFILM FORMERS See Parent Genus (Roseburia)	COGEM PATHOGENICITY See Parent Genus (Roseburia)