Datapunk Opus23 | Kluyvera

Kluyvera

RANK: Genus

TAXONOMY: cellular organisms -> Bacteria -> Proteobacteria -> Gammaproteobacteria -> Enterobacteriales -> Enterobacteriaceae -> Kluyvera

OVERVIEW:

Enterobacteriaceae like Kluyvera are not very friendly and tend to thrive in the inflamed gut. Small rod-shaped cells, 0.5–0.7 × 2–3 µm, conforming to the general definition of the family Enterobacteriaceae. Gram negative. Motile, with peritrichous flagella. Contains the enterobacterial common antigen. Facultatively anaerobic. Catalase positive (weak). Oxidase negative. Nonpigmented. Ferment, rather than oxidize, d-glucose and other carbohydrates. Reduce nitrate to nitrite. Positive for indole production, methyl red, citrate utilization (Simmons), ornithine decarboxylase, motility at 36°C, growth in the presence of cyanide (KCN test), malonate utilization, and esculin hydrolysis. Ferment d-glucose, lactose, sucrose, d-mannitol, salicin, l-arabinose, raffinose, l-rhamnose, maltose, d-xylose, trehalose, cellobiose, α-methyl-d-glucoside, melibiose, mucate, d-mannose, and d-galactose. Produce visible gas during fermentation. Produce large amounts of α-ketoglutaric acid during the fermentation of d-glucose. Negative for Voges–Proskauer, H2S production (TSI), urea hydrolysis, phenylalanine deaminase, arginine dihydrolase, gelatin hydrolysis (22°C), lipase (corn oil), DNase, and the fermentation of dulcitol, adonitol, myo-inositol, erythritol, and d-arabitol. Susceptible to colistin, sulfadiazine, gentamicin, kanamycin, tetracycline, and chloramphenicol (disk diffusion method on Mueller–Hinton agar); resistant to carbenicillin; penicillin, ampicillin, and cephalothin; variable susceptibility to nalidixic acid and streptomycin.The mol% G + C of the DNA is: 55.1–56.6.Type species: Kluyvera ascorbata

This genus contains microbial species that can reside in the human gastrointestinal tract. [PMC 4262072]

Microbial Abundance Data: Kluyvera (Percent of total population with standard deviation [PMID: 22698087])
Group 1				Group 2					Group 3			Group 4
Group 1 Avg	Buccal Mucosa	Keratinized Gingiva	Hard Palate	Group 2 Avg	Throat	Throat	Tonsils	Saliva	Group 3 Avg	Supragingival Plaque	Subgingival Plaque	Stool
0.000 % (0.001)	0.000 % (0.001)	0.000 % (0.000)	0.000 % (0.002)	0.000 % (0.001)	0.000 % (0.003)	0.000 % (0.000)	0.000 % (0.000)	0.000 % (0.000)	0.000 % (0.000)	0.000 % (0.000)	0.000 % (0.000)	0.089 % (0.187)

TAGS

Keystone	Core species	Type species	Pathogen	Dysbiosis associated	Flora/ commensal	Gut associated	Probiotic
Leanness	Obesity	Skin microbiome	Fecal distribution	Oral microbiome	Vaginal microbiome	Butyrate producer	Catalase producer
Histamine producer	Food fermenter	Amylolytic	Propionate producer	Nitrifying

DESCENDANTS Kluyvera ascorbata Kluyvera cryocrescens Kluyvera georgiana Kluyvera intermedia Kluyvera sp. SR5.1 environmental samples	INTERACTIONS ENHANCES Bacteroidales Bacteroides Odoribacter Peptococcaceae INHIBITS Bifidobacterium Coriobacteriales Adlercreutzia Collinsella Porphyromonas Prevotella Clostridium Clostridiales incertae sedis Clostridiales Family XIII. Incertae Sedis Blautia Coprococcus Dorea Lachnospiraceae Ruminococcaceae Ruminococcus Dialister Campylobacteraceae Erysipelotrichaceae	KEGG PATHWAYS 2-Oxocarboxylic acid metabolism ABC transporters Alanine, aspartate and glutamate metabolism Amino sugar and nucleotide sugar metabolism Aminoacyl-tRNA biosynthesis Aminobenzoate degradation Arachidonic acid metabolism Arginine and proline metabolism Arginine biosynthesis Ascorbate and aldarate metabolism Atrazine degradation Bacterial chemotaxis Bacterial secretion system Base excision repair Benzoate degradation Biosynthesis of amino acids Biosynthesis of antibiotics Biosynthesis of secondary metabolites Biosynthesis of siderophore group nonribosomal peptides Biosynthesis of unsaturated fatty acids Biotin metabolism Butanoate metabolism C5-Branched dibasic acid metabolism Caprolactam degradation Carbapenem biosynthesis Carbon metabolism Cationic antimicrobial peptide (CAMP) resistance Chloroalkane and chloroalkene degradation Chlorocyclohexane and chlorobenzene degradation Citrate cycle (TCA cycle) Cyanoamino acid metabolism Cysteine and methionine metabolism D-Alanine metabolism D-Arginine and D-ornithine metabolism D-Glutamine and D-glutamate metabolism DNA replication Degradation of aromatic compounds Dioxin degradation Ether lipid metabolism Fatty acid biosynthesis Fatty acid degradation Fatty acid metabolism Flagellar assembly Fluorobenzoate degradation Folate biosynthesis Fructose and mannose metabolism Galactose metabolism Geraniol degradation Glutathione metabolism Glycerolipid metabolism Glycerophospholipid metabolism Glycine, serine and threonine metabolism Glycolysis / Gluconeogenesis Glyoxylate and dicarboxylate metabolism Histidine metabolism Homologous recombination Inositol phosphate metabolism Insulin resistance Limonene and pinene degradation Lipoic acid metabolism Lipopolysaccharide biosynthesis Lysine biosynthesis Lysine degradation Metabolic pathways Methane metabolism Microbial metabolism in diverse environments Mismatch repair Monobactam biosynthesis Naphthalene degradation Nicotinate and nicotinamide metabolism Nitrogen metabolism Nitrotoluene degradation Nonribosomal peptide structures Novobiocin biosynthesis Nucleotide excision repair One carbon pool by folate Other glycan degradation Oxidative phosphorylation Pantothenate and CoA biosynthesis Pentose and glucuronate interconversions Pentose phosphate pathway Peptidoglycan biosynthesis Phenylalanine metabolism Phenylalanine, tyrosine and tryptophan biosynthesis Phosphotransferase system (PTS) Polyketide sugar unit biosynthesis Porphyrin and chlorophyll metabolism Propanoate metabolism Protein export Purine metabolism Pyrimidine metabolism Pyruvate metabolism RNA degradation RNA polymerase Riboflavin metabolism Ribosome Selenocompound metabolism Starch and sucrose metabolism Streptomycin biosynthesis Styrene degradation Sulfur metabolism Sulfur relay system Synthesis and degradation of ketone bodies Taurine and hypotaurine metabolism Terpenoid backbone biosynthesis Thiamine metabolism Toluene degradation Tryptophan metabolism Two-component system Tyrosine metabolism Ubiquinone and other terpenoid-quinone biosynthesis Valine, leucine and isoleucine biosynthesis Valine, leucine and isoleucine degradation Vancomycin resistance Vitamin B6 metabolism Xylene degradation alpha-Linolenic acid metabolism beta-Alanine metabolism beta-Lactam resistance CLUSTERS WITH	METABOLOMICS NUTRIENTS/ SUBSTRATES Raffinose D-Glucose Cellobiose Iron supplements [parent] Acetoin [parent] D-Mannitol L-Arabinose D-Trehalose D-Lactose D-Xylose D-Galactose D-Mannose L-Rhamnose D-Maltose ENDPRODUCTS 2,3-Butanediol [parent] INHIBITED BY Pomegranate ellagitannins [parent] L-Phenylalanine Pomegranate ellagitannins ENHANCED BY Aspartame [parent] Aspartame L-Serine L-Proline L-Glutamic acid BIOTRANSFORMS BIOTRANFORM
ANTIBIOTIC RESISTANCE Spectinomycin (ant3ia) Streptomycin (ant3ia) Monobactam (bl2be_ctxm) Cephalosporin ii (bl2be_ctxm) Cephalosporin iii (bl2be_ctxm) Penicillin (bl2be_ctxm) Cephalosporin i (bl2be_ctxm) Ceftazidime (bl2be_ctxm) Cephalosproin (bl1_ampc)	BIOFILM FORMERS	COGEM PATHOGENICITY

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