Datapunk Opus23 | Barnesiella

Barnesiella

RANK: Genus

TAXONOMY: Bacteria -> Bacteroidetes/Chlorobi group -> Bacteroidetes -> Bacteroidia -> Bacteroidales -> Porphyromonadaceae -> Barnesiella

OVERVIEW:

Rods (0.8–1.6 × 1.7–11 µm). Nonsporeforming. Nonmotile. Gram-negative. Obligately anaerobic. On Eggerth–Gagnon agar, colonies are 1–2 mm in diameter, gray to off-white–gray, circular, entire, slightly convex, and smooth. Saccharolytic, with a strictly fermentative type of metabolism. Acetic and succinic acids are the main fermentation products. Growth is inhibited on a medium containing 20% bile. Esculin is hydrolyzed. Indole-negative. The predominant menaquinones are MK-11 and MK-12. Isolated from the chicken cecum.

DNA G+C content (mol%): 52. Type species: Barnesiella viscericola

Characterization of the fecal microbiota of patients undergoing allogeneic hematopoietic stem cell transplantation demonstrated that intestinal colonization with Barnesiella confers resistance to intestinal domination and bloodstream infection with VRE. Our studies indicate that obligate anaerobic bacteria belonging to the Barnesiella genus enable clearance of intestinal VRE colonization and may provide novel approaches to prevent the spread of highly antibiotic-resistant bacteria. [PMID: 23319552]

This genus contains microbial species that can reside in the human gastrointestinal tract. [PMC 4262072] The reintroduction of anaerobic flora with high levels of Barnesiella sp. can clear intestines from highly abundant vancomycin-resistant Enteroccocus in mice [PMC 3861043].

Microbial Abundance Data: Barnesiella (Percent of total population with standard deviation [PMID: 22698087])
Group 1				Group 2					Group 3			Group 4
Group 1 Avg	Buccal Mucosa	Keratinized Gingiva	Hard Palate	Group 2 Avg	Throat	Throat	Tonsils	Saliva	Group 3 Avg	Supragingival Plaque	Subgingival Plaque	Stool
0.002 % (0.014)	0.002 % (0.013)	0.002 % (0.017)	0.003 % (0.013)	0.003 % (0.018)	0.003 % (0.013)	0.001 % (0.008)	0.000 % (0.003)	0.006 % (0.048)	0.001 % (0.017)	0.000 % (0.004)	0.002 % (0.030)	1.173 % (2.218)

TAGS

Keystone	Core species	Type species	Pathogen	Dysbiosis associated	Flora/ commensal	Gut associated	Probiotic
Leanness	Obesity	Skin microbiome	Fecal distribution	Oral microbiome	Vaginal microbiome	Butyrate producer	Catalase producer
Histamine producer	Food fermenter	Amylolytic	Propionate producer	Nitrifying

DESCENDANTS Barnesiella intestinihominis Barnesiella sp. EBA4-14 Barnesiella viscericola environmental samples	INTERACTIONS ENHANCES Bacteroidales Bacteroides Odoribacter Peptococcaceae INHIBITS Enterococcus Bifidobacterium Coriobacteriales Adlercreutzia Collinsella Porphyromonas Prevotella Clostridium Clostridiales incertae sedis Clostridiales Family XIII. Incertae Sedis Blautia Coprococcus Dorea Lachnospiraceae Ruminococcaceae Ruminococcus Dialister Campylobacteraceae Erysipelotrichaceae	KEGG PATHWAYS 2-Oxocarboxylic acid metabolism ABC transporters Alanine, aspartate and glutamate metabolism Amino sugar and nucleotide sugar metabolism Aminoacyl-tRNA biosynthesis Arginine and proline metabolism Arginine biosynthesis Ascorbate and aldarate metabolism Bacterial secretion system Base excision repair Biosynthesis of amino acids Biosynthesis of antibiotics Biosynthesis of secondary metabolites Biosynthesis of unsaturated fatty acids Biotin metabolism Butanoate metabolism C5-Branched dibasic acid metabolism Carbapenem biosynthesis Carbon metabolism Cationic antimicrobial peptide (CAMP) resistance Chloroalkane and chloroalkene degradation Citrate cycle (TCA cycle) Cyanoamino acid metabolism Cysteine and methionine metabolism D-Alanine metabolism D-Glutamine and D-glutamate metabolism DNA replication Ether lipid metabolism Fatty acid biosynthesis Fatty acid degradation Fatty acid metabolism Folate biosynthesis Fructose and mannose metabolism Galactose metabolism Glutathione metabolism Glycerolipid metabolism Glycerophospholipid metabolism Glycine, serine and threonine metabolism Glycolysis / Gluconeogenesis Glyoxylate and dicarboxylate metabolism Histidine metabolism Homologous recombination Lipopolysaccharide biosynthesis Lysine biosynthesis Lysine degradation Metabolic pathways Methane metabolism Microbial metabolism in diverse environments Mismatch repair Monobactam biosynthesis Nicotinate and nicotinamide metabolism Nitrogen metabolism Novobiocin biosynthesis Nucleotide excision repair One carbon pool by folate Other glycan degradation Oxidative phosphorylation Pantothenate and CoA biosynthesis Pentose and glucuronate interconversions Pentose phosphate pathway Peptidoglycan biosynthesis Phenylalanine metabolism Phenylalanine, tyrosine and tryptophan biosynthesis Phosphonate and phosphinate metabolism Polyketide sugar unit biosynthesis Porphyrin and chlorophyll metabolism Propanoate metabolism Protein export Purine metabolism Pyrimidine metabolism Pyruvate metabolism RNA degradation RNA polymerase Riboflavin metabolism Ribosome Secondary bile acid biosynthesis Selenocompound metabolism Sphingolipid metabolism Starch and sucrose metabolism Streptomycin biosynthesis Sulfur metabolism Sulfur relay system Taurine and hypotaurine metabolism Terpenoid backbone biosynthesis Thiamine metabolism Tryptophan metabolism Two-component system Tyrosine metabolism Ubiquinone and other terpenoid-quinone biosynthesis Valine, leucine and isoleucine biosynthesis Valine, leucine and isoleucine degradation Vancomycin resistance Vitamin B6 metabolism alpha-Linolenic acid metabolism beta-Alanine metabolism beta-Lactam resistance CLUSTERS WITH	METABOLOMICS NUTRIENTS/ SUBSTRATES Esculin ENDPRODUCTS Acetic acid Succinic acid INHIBITED BY Bile ENHANCED BY BIOTRANSFORMS BIOTRANFORM Trimethylamine Trimethylamine-N-oxide (TMAO)
ANTIBIOTIC RESISTANCE	BIOFILM FORMERS	COGEM PATHOGENICITY

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