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Parabacteroides merdae

RANK: Species

TAXONOMY: Bacteroidetes/Chlorobi group -> Bacteroidetes -> Bacteroidia -> Bacteroidales -> Porphyromonadaceae -> Parabacteroides -> Parabacteroides merdae

OVERVIEW:

This genus is closely related to the genus Bacteroides. These genera constitute the most abundant members of the intestinal microflora of mammals. Typically they are symbionts, but they can become opportunistic pathogens in the peritoneal (intra-abdominal) cavity. These organisms produce many extracellular enzymes which assist in the breakdown of complex plant polysaccharides such as cellulose and hemicellulose and host-derived polysaccharides such as mucopolysaccharides.Parabacteroides merdae. Parabacteroides merdae is part of normal human gut flora. In one comprehensive 16S rDNA sequence-based enumeration of the colonic microbiota of three healthy adult humans it represents, on average, 0.262% of all 16S rDNA sequences and 0.550% of the sequences in its division (Eckburg et. al. (2005)).

This species has been identified as a resident in the human gastrointestinal tract based on the phylogenetic framework of its small subunit ribosomal RNA gene sequences.[PMC 4262072]

COGEM

COGEM released a comprehensive database of pathogenicity assessment of around 2575 bacterial species in 2011. The database ranks the pathogenicity of species on a scale of 1 to 4. Parabacteroides merdae ranks on this scale:

Identified as a 'core species' of the human gut microbiome. [PMID: 23222524]

TAGS

Keystone	Core species	Type species	Pathogen	Dysbiosis associated	Flora/ commensal	Gut associated	Probiotic
Leanness	Obesity	Skin microbiome	Fecal distribution	Oral microbiome	Vaginal microbiome	Butyrate producer	Catalase producer
Histamine producer	Food fermenter	Amylolytic	Propionate producer	Nitrifying	Biofilm producer

INTERACTIONS ENHANCES Bacteroidales Bacteroides Odoribacter Peptococcaceae INHIBITS Bifidobacterium Coriobacteriales Adlercreutzia Collinsella Porphyromonas Prevotella Clostridium Clostridiales incertae sedis Clostridiales Family XIII. Incertae Sedis Blautia Coprococcus Dorea Lachnospiraceae Ruminococcaceae Ruminococcus Dialister Campylobacteraceae Erysipelotrichaceae	KEGG PATHWAYS CLUSTERS WITH	METABOLOMICS NUTRIENTS/ SUBSTRATES ENDPRODUCTS INHIBITED BY ENHANCED BY Ketogenic diet [parent] Proton-pump inhibitors (PPI) [parent] Resistant starch (type IV) [parent] BIOTRANSFORMS BIOTRANFORM Trimethylamine-N-oxide (TMAO) [parent] Trimethylamine [parent]
ANTIBIOTIC RESISTANCE See Parent Genus (Parabacteroides)	BIOFILM FORMERS See Parent Genus (Parabacteroides)	COGEM PATHOGENICITY See Parent Genus (Parabacteroides)