Oxalobacter formigenes

RANK: Species

TAXONOMY: Bacteria -> Proteobacteria -> Betaproteobacteria -> Burkholderiales -> Oxalobacteraceae -> Oxalobacter -> Oxalobacter formigenes


'Oxalobacter formigenes' is an oxalate-degrading anaerobic bacterium that colonizes the large intestine of numerous vertebrates, including humans. O. formigenes and humans share a beneficial symbiosis. Quinolone, a broad-spectrum antibiotic, kills O. formigenes. If a person's gastrointestinal tract lacks this bacterium, and therefore lacks the primary source for the Oxalyl-CoA decarboxylase enzyme, then the GI tract cannot degrade dietary oxalates which on digestion get absorbed easily and after some Vit B6 modulated partial metabolical degradation in the body, is excreted in the kidney where it precipitates with calcium forming calcium oxalate kidney stones.[http://www.urologystone.com/CH18WhatsNew/2001AUA.html (interim reference, describes two other studies)] Synonyms : strain OxB, CIP 106513, ATCC 35274 Direct sub-taxa of Oxalobacter formigenes: Oxalobacter formigenes DSM 4420, Oxalobacter formigenes HOxBLS, Oxalobacter formigenes OXCC13 

This species has been identified as a resident in the human gastrointestinal tract based on the phylogenetic framework of its small subunit ribosomal RNA gene sequences.[PMC 4262072]

Gut associated
Flora/ commensal
Type species