Datapunk Opus23 | Lactobacillus acidophilus

Lactobacillus acidophilus

RANK: Species

TAXONOMY: Terrabacteria group -> Firmicutes -> Bacilli -> Lactobacillales -> Lactobacillaceae -> Lactobacillus -> Lactobacillus acidophilus

OVERVIEW:

This bacterium colonizes most densely in the small intestine, where it helps maintain the integrity of the intestinal wall, ensure proper nutrient absorption, and support healthy overall digestive function. Research shows that acidophilus also can help ease occasional digestive discomfort. In a double blind placebo controlled study, patients taking this probiotic strain experienced significantly more relief from their symptoms than patients taking a placebo. A separate meta-analysis found that probiotics containing acidophilus help to alleviate occasional diarrhea, and a third study found that supplements containing both acidophilus and B. bifidum help modulate the response of microflora in the intestines to the effects of antibiotics. Additional preliminary research shows that acidophilus may help boost immune system activity and support vaginal health in women.Identified as a constituent of the oral microbiome by Human Oral Microbiome Database. Animal studies of NCFM have indicated that it reduces intestinal pain by inducing u-opioid and canabinoid receptors in the intestines (of animals), but this effect has not been sufficiently shown in humans yet. L. acidophilus may produce vitamin K and lactase. Some strains may produce bacteriocins such as acidolin, acidophilin and lactocidin.

This species has been identified as a resident in the human gastrointestinal tract based on the phylogenetic framework of its small subunit ribosomal RNA gene sequences.[PMC 4262072]

COGEM

COGEM released a comprehensive database of pathogenicity assessment of around 2575 bacterial species in 2011. The database ranks the pathogenicity of species on a scale of 1 to 4. Lactobacillus acidophilus ranks on this scale:

TAGS

Keystone	Core species	Type species	Pathogen	Dysbiosis associated	Flora/ commensal	Gut associated	Probiotic
Leanness	Obesity	Skin microbiome	Fecal distribution	Oral microbiome	Vaginal microbiome	Butyrate producer	Catalase producer
Histamine producer	Food fermenter	Amylolytic	Propionate producer	Nitrifying	Biofilm producer

INTERACTIONS INHIBITS Clostridioides difficile Enterococcus	KEGG PATHWAYS CLUSTERS WITH Group 4 Streptococcus mutans Leuconostoc mesenteroides Lactobacillus salivarius Lactobacillus acidophilus Bifidobacterium adolescentis Streptococcus thermophilus Lactobacillus gasseri Pediococcus pentosaceus Clostridium perfringens Listeria innocua Lactobacillus sakei Bifidobacterium longum Lactobacillus johnsonii Streptococcus sanguinis Lactobacillus casei Lactobacillus brevis Streptococcus gordonii Lactobacillus delbrueckii Group 132 Lactobacillus acidophilus Fusobacterium nucleatum Group 7 Staphylococcus epidermidis Leuconostoc mesenteroides Lactobacillus acidophilus Lactobacillus plantarum Bacillus cereus Streptococcus thermophilus Listeria monocytogenes Pediococcus pentosaceus Bacteroides fragilis Staphylococcus saprophyticus Clostridium perfringens Listeria innocua Corynebacterium jeikeium Lactobacillus sakei Streptococcus pneumoniae Staphylococcus aureus Streptococcus sanguinis Streptococcus pyogenes Lactobacillus casei Pseudomonas aeruginosa Lactobacillus brevis Enterococcus faecalis Streptococcus agalactiae Fusobacterium nucleatum Lactococcus lactis Streptococcus gordonii Staphylococcus haemolyticus Group 2 Leuconostoc mesenteroides Lactobacillus salivarius Lactobacillus acidophilus Bifidobacterium adolescentis Lactobacillus plantarum Streptococcus thermophilus Oenococcus oeni Listeria monocytogenes Lactobacillus gasseri Chloroflexus aurantiacus Bacillus pumilus Pediococcus pentosaceus Bacillus licheniformis Listeria innocua Lactobacillus sakei Clostridium acetobutylicum Bifidobacterium longum Lactobacillus johnsonii Lactobacillus brevis Lactococcus lactis Streptococcus gordonii Lactobacillus delbrueckii Group 5 Staphylococcus epidermidis Lactobacillus acidophilus Bifidobacterium adolescentis Chloroflexus aurantiacus Neisseria gonorrhoeae Saccharophagus degradans Cytophaga hutchinsonii Bacteroides fragilis Clostridium perfringens Enterobacter Propionibacterium acnes Gramella forsetii Clostridium acetobutylicum Staphylococcus aureus Porphyromonas gingivalis Bifidobacterium longum Colwellia psychrerythraea Pseudomonas aeruginosa Bacteroides thetaiotaomicron Haemophilus influenzae Peptoclostridium difficile Fusobacterium nucleatum	METABOLOMICS NUTRIENTS/ SUBSTRATES D-Glucose Ellagic acid [parent] D-Glucose [parent] CO2 [parent] α-Glucan [parent] ENDPRODUCTS Acetylcholine [parent] γ-Amino butyric acid (GABA) [parent] Trimethylamine [parent] Lactic acid [parent] Vitamin K Urolithins [parent] Lactate [parent] Lactic acid Vitamin B12 [parent] INHIBITED BY Stevia [parent] Laminaria hyperborea (curvie) [parent] Chemotherapy [parent] Magnesium-deficient diet [parent] Glyphosphate [parent] High fat diet [parent] Sucralose (Splenda) [parent] ENHANCED BY Sesame cake/meal [parent] Almonds/ almond skins [parent] Navy bean (Cooked) [parent] Magnesium [parent] Daesiho-tang (DSHT) [parent] Resveratrol [parent] Proton-pump inhibitors (PPI) [parent] Laminaria digitata (oarweed) [parent] Melatonin [parent] BIOTRANSFORMS CB2 receptor expression Linoleic acid (LA) [parent] Linolenic acid (CLnA) [parent] Bile salts BIOTRANFORM 10‐Hydroxy‐cis‐12‐octadecenoate (HYA) [parent] Trans-11 conjugate linoleic acid (CLA) [parent] Cis-9 conjugate linoleic acid (CLA) [parent] Cis-15 conjugate linolenic acids (CLnA) [parent] Cis-9 conjugate linolenic acids (CLnA) [parent] 10-Hydroxyoctadecanoate (HYB) [parent] Trans-11 conjugate linolenic acids (CLnA) [parent]
ANTIBIOTIC RESISTANCE See Parent Genus (Lactobacillus)	BIOFILM FORMERS See Parent Genus (Lactobacillus)	COGEM PATHOGENICITY See Parent Genus (Lactobacillus)

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