Porphyromonas gingivalis

RANK: Species

TAXONOMY: Bacteroidetes/Chlorobi group -> Bacteroidetes -> Bacteroidia -> Bacteroidales -> Porphyromonadaceae -> Porphyromonas -> Porphyromonas gingivalis

OVERVIEW:

Identified as a constituent of the oral microbiome by Human Oral Microbiome Database. Identified as constituent of vaginal microbiome. [PMID:23282177] Porphyromonas gingivalis belongs to the phylum Bacteroidetes and is a nonmotile, Gram-negative, rod-shaped, anaerobic, pathogenic bacterium. It forms black colonies on blood agar. It is found in the oral cavity, where it is implicated in certain forms of periodontal disease, as well as the upper gastrointestinal tract, respiratory tract, and in the colon. It has also been isolated from women with bacterial vaginosis. Collagen degradation observed in chronic periodontal disease results in part from the collagenase enzymes of this species. It has been shown in an in vitro study that P. gingivalis can invade human gingival fibroblasts and can survive in them in the presence of considerable concentrations of antibiotics. P. gingivalis also invades gingival epithelial cells in high numbers, in which cases both bacteria and epithelial cells survive for extended periods of time. High levels of specific antibodies can be detected in patients harboring P. gingivalis. In addition, P. gingivalis has been linked to rheumatoid arthritis. It contains the enzyme peptidyl-arginine deiminase, which is involved in citrullination. Patients with rheumatoid arthritis have an increased incidence of periodontal disease[citation needed] and antibodies against the bacterium are significantly more common in these patients.

This species has been identified as a resident in the human gastrointestinal tract based on the phylogenetic framework of its small subunit ribosomal RNA gene sequences.[PMC 4262072]

2

COGEM

COGEM released a comprehensive database of pathogenicity assessment of around 2575 bacterial species in 2011. The database ranks the pathogenicity of species on a scale of 1 to 4. Porphyromonas gingivalis ranks 2 on this scale: Species that can cause diseases in humans or animals, which are unlikely to spread in the human population and for which an adequate prophylaxis or therapy exists

TAGS

Keystone	Core species	Type species	Pathogen	Dysbiosis associated	Flora/ commensal	Gut associated	Probiotic
Leanness	Obesity	Skin microbiome	Fecal distribution	Oral microbiome	Vaginal microbiome	Butyrate producer	Catalase producer
Histamine producer	Food fermenter	Amylolytic	Propionate producer	Nitrifying	Biofilm producer

INTERACTIONS ENHANCES Bacteroidales Bacteroides Odoribacter Peptococcaceae INHIBITS Bifidobacterium Coriobacteriales Adlercreutzia Collinsella Porphyromonas Prevotella Clostridium Clostridiales incertae sedis Clostridiales Family XIII. Incertae Sedis Blautia Coprococcus Dorea Lachnospiraceae Ruminococcaceae Ruminococcus Dialister Campylobacteraceae Erysipelotrichaceae INHIBITED BY Bifidobacterium Coriobacteriales Adlercreutzia Collinsella Bacteroidales Bacteroides Porphyromonadaceae Odoribacter Parabacteroides Porphyromonas Prevotella Rikenellaceae Alistipes Turicibacter Streptococcus Clostridiales Catabacteriaceae Clostridium Clostridiales incertae sedis Peptoniphilus Clostridiales Family XIII. Incertae Sedis Lachnospiraceae Blautia Lachnospiraceae Coprococcus Dorea Eubacterium Lachnobacterium Lachnospira Roseburia Lachnospiraceae Peptococcaceae Ruminococcaceae Ruminiclostridium Acetivibrio Eubacterium Faecalibacterium Oscillospira Ruminococcus Acidaminococcus Dialister Phascolarctobacterium Veillonella Rubrivivax Alcaligenaceae Oxalobacter Bilophila Desulfovibrio Campylobacteraceae Enterobacteriaceae Escherichia Erysipelotrichaceae Erysipelotrichaceae Holdemania Akkermansia	KEGG PATHWAYS CLUSTERS WITH Group 22 Streptococcus mutans Lactobacillus salivarius Porphyromonas gingivalis Streptococcus sanguinis Streptococcus pyogenes Treponema denticola Streptococcus gordonii Streptococcus suis Gramella forsetii Group 160 Porphyromonas gingivalis Campylobacter concisus Group 47 Streptococcus mutans Porphyromonas gingivalis Streptococcus sanguinis Treponema denticola Campylobacter concisus Fusobacterium nucleatum Streptococcus gordonii Campylobacter curvus Propionibacterium acnes Group 5 Staphylococcus epidermidis Lactobacillus acidophilus Bifidobacterium adolescentis Chloroflexus aurantiacus Neisseria gonorrhoeae Saccharophagus degradans Cytophaga hutchinsonii Bacteroides fragilis Clostridium perfringens Enterobacter Propionibacterium acnes Gramella forsetii Clostridium acetobutylicum Staphylococcus aureus Porphyromonas gingivalis Bifidobacterium longum Colwellia psychrerythraea Pseudomonas aeruginosa Bacteroides thetaiotaomicron Haemophilus influenzae Peptoclostridium difficile Fusobacterium nucleatum	METABOLOMICS NUTRIENTS/ SUBSTRATES ENDPRODUCTS INHIBITED BY Epicatechin Whole-grain barley [parent] (+)-Catechin Garlic (allicin) [parent] β-Glucan [parent] ENHANCED BY BIOTRANSFORMS BIOTRANFORM
ANTIBIOTIC RESISTANCE See Parent Genus (Porphyromonas)	BIOFILM FORMERS See Parent Genus (Porphyromonas)	COGEM PATHOGENICITY See Parent Genus (Porphyromonas)

OPUS 23™ IS A REGISTERED TRADEMARK ® OF DATAPUNK BIOINFORMATICS, LLC. COPYRIGHT © 2015-2023. ALL RIGHTS RESERVED. |