Collinsella

RANK: Genus

TAXONOMY: Bacteria -> Terrabacteria group -> Actinobacteria -> Coriobacteriia -> Coriobacteriales -> Coriobacteriaceae -> Collinsella

OVERVIEW:

'Collinsella' is a genus of Actinobacteria, in the family Coriobacteriaceae. Gram-stain-positive, obligatory anaerobic organism which forms chains of rods (0.3–0.7 × 1.2–4.3 µm). Does not form spores or flagella. Colonies are produced in 2 d at 37°C on EG agar in an anaerobic jar containing 100% CO2. Fermentation products of glucose are ethanol, formate, hydrogen, and lactate. Cell wall contains an A4 type peptidoglycan. The 16S rDNA sequence analysis shows that the organism is a member of the family Coriobacteriaceae, which also includes the genera Atopobium, Coriobacterium, Cryptobacterium, Denitrobacterium, Eggerthella, Olsenella, and Slackia.

DNA G+C content (mol%): 60–65 (HPLC).

Type species: Collinsella aerofaciens

This genus contains microbial species that can reside in the human gastrointestinal tract. [PMC 4262072]

Association with rheumatoid arthritis: Collinsella genus correlated strongly with high levels of three metabolites (beta-alanine, alpha-aminoadipic acid, and asparagine). The role of the RA-associated bacteria Collinsella was confirmed using a human epithelial cell line and a humanized mouse model of arthritis consisting of transgenic mice in which arthritis was induced by immunization with type II collagen (as previously described by Taneja et al., 2007). Collinsella increased gut permeability by reducing the expression of tight junction protein in the human intestinal epithelial cell line CACO-2, and it induced production of the proinflammatory cytokine interleukin (IL)-17A. In addition, Collinsella enhanced disease severity in a humanized mouse model. The dysbiotic gut microbiota in patients with RA stemmed from an expansion of rare microbial lineages like Eggerthella and Collinsella and from a decrease in the abundant beneficial genera like Faecalibacterium. A gut microbial profile for RA patients was identified based on the abundance of the three genera: Collinsella, Eggerthella, and Faecalibacterium.[PMID 27448997]

A significant association was observed between commensal microbial composition and clinical response to anti-PD-1-based immunotherapy. Bacterial species more abundant in responders included Bifidobacterium longum, Collinsella aerofaciens, and Enterococcus faecium. PMID: 29302014


Pathogen
Gut associated
Dysbiosis associated
Fecal distribution
Microbial Abundance Data: Collinsella
Percent of total population with standard deviation [PMID: 22698087]. Percentages > 1% highlighted.
Buccal
Mucosa
Keratinized
Gingiva
Hard
Palate
Throat
Tonsils
Saliva
Stool
0.000 %
(0.002)
0.000 %
(0.000)
0.002 %
(0.016)
0.001 %
(0.007)
0.000 %
(0.000)
0.000 %
(0.002)
0.100 %
(0.216)
Name
Rank
Client %
Avg %
Avg StdDev
Client StdDev
Collinsella
genus
0.42
0.100
0.216
+1
DESCENDANTS
INTERACTIONS
Collinsella enhances growth of
  • Bacteroidales
  • Bacteroides
  • Odoribacter
  • Peptococcaceae

  • Collinsella inhibits growth of
  • Adlercreutzia
  • Bifidobacterium
  • Blautia
  • Campylobacteraceae
  • Clostridiales Family XIII. Incertae Sedis
  • Clostridiales incertae sedis
  • Clostridium
  • Collinsella
  • Coprococcus
  • Coriobacteriales
  • Dialister
  • Dorea
  • Erysipelotrichaceae
  • Lachnospiraceae
  • Porphyromonas
  • Prevotella
  • Ruminococcaceae
  • Ruminococcus

  • Collinsella growth inhibited by
  • Acetivibrio
  • Acidaminococcus
  • Adlercreutzia
  • Akkermansia
  • Alcaligenaceae
  • Alistipes
  • Bacteroidales
  • Bacteroides
  • Bifidobacterium
  • Bilophila
  • Blautia
  • Campylobacteraceae
  • Catabacteriaceae
  • Clostridiales
  • Clostridiales Family XIII. Incertae Sedis
  • Clostridiales incertae sedis
  • Clostridium
  • Collinsella
  • Coprococcus
  • Coriobacteriales
  • Desulfovibrio
  • Dialister
  • Dorea
  • Enterobacteriaceae
  • Erysipelotrichaceae
  • Escherichia
  • Eubacterium
  • Faecalibacterium
  • Holdemania
  • Lachnobacterium
  • Lachnospira
  • Lachnospiraceae
  • Odoribacter
  • Oscillospira
  • Oxalobacter
  • Parabacteroides
  • Peptococcaceae
  • Peptoniphilus
  • Phascolarctobacterium
  • Porphyromonadaceae
  • Porphyromonas
  • Prevotella
  • Rikenellaceae
  • Roseburia
  • Rubrivivax
  • Ruminiclostridium
  • Ruminococcaceae
  • Ruminococcus
  • Streptococcus
  • Turicibacter
  • Veillonella
  • METABOLOMICS