Lactobacillus acidophilusRANK: Species
TAXONOMY: Terrabacteria group -> Firmicutes -> Bacilli -> Lactobacillales -> Lactobacillaceae -> Lactobacillus -> Lactobacillus acidophilus
This bacterium colonizes most densely in the small intestine, where it helps maintain the integrity of the intestinal wall, ensure proper nutrient absorption, and support healthy overall digestive function. Research shows that acidophilus also can help ease occasional digestive discomfort. In a double blind placebo controlled study, patients taking this probiotic strain experienced significantly more relief from their symptoms than patients taking a placebo. A separate meta-analysis found that probiotics containing acidophilus help to alleviate occasional diarrhea, and a third study found that supplements containing both acidophilus and B. bifidum help modulate the response of microflora in the intestines to the effects of antibiotics. Additional preliminary research shows that acidophilus may help boost immune system activity and support vaginal health in women.Identified as a constituent of the oral microbiome by Human Oral Microbiome Database. Animal studies of NCFM have indicated that it reduces intestinal pain by inducing u-opioid and canabinoid receptors in the intestines (of animals), but this effect has not been sufficiently shown in humans yet. L. acidophilus may produce vitamin K and lactase. Some strains may produce bacteriocins such as acidolin, acidophilin and lactocidin.
This species has been identified as a resident in the human gastrointestinal tract based on the phylogenetic framework of its small subunit ribosomal RNA gene sequences.[PMC 4262072]