Streptococcus salivarius

RANK: Species

TAXONOMY: Terrabacteria group -> Firmicutes -> Bacilli -> Lactobacillales -> Streptococcaceae -> Streptococcus -> Streptococcus salivarius


This probiotic strain is found in the oral cavity’s mucus membranes and is known for its ability to produce BLIS (bacteriocin-like inhibitory substances), which inhibit the ability of other undesirable bacteria to grow. Research has found that the 10 percent of the population who naturally carry BLIS-producing strains of oral bacteria have significantly fewer sore throats. Studies have associated S. salivarius K12 with better ear health in children, “significantly” reduced dental plaque scores, increased levels of interferon gamma in saliva (an immune marker), and significant reduction in volatile sulphur compounds that cause bad breath. S. salivarius M18 is also found predominantly in oral mucosa and, like the K12 strain, it also produces BLIS. S. salivarius M18 is most active in specific areas on the gums and teeth. S. salivarius M18 also promotes a healthy inflammatory response in the gums. Identified as a constituent of the oral microbiome by Human Oral Microbiome Database. Identified as constituent of vaginal microbiome. [PMID:23282177]

This species has been identified as a resident in the human gastrointestinal tract based on the phylogenetic framework of its small subunit ribosomal RNA gene sequences.[PMC 4262072]

Food fermenter
Gut associated
Oral microbiome
Vaginal microbiome
Client %
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Streptococcus salivarius