Datapunk Opus 23 Pro

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MAPPER Global Analysis mode

When you first load a map into MAPPER you start in 'Global Analysis' mode, where the map displays gene data as elements of the current client's genotype.

Interpreting MAPPER gene data

It's perhaps easiest to think a gene 'box' in MAPPER as the equivalent of the battery icon on a smartphone: If there are bars all across the battery icon it's probably at full charge; however as the battery loses power, the bars get shorter from right to left. MAPPER uses the same iconography to tell you about the status of the genes in its network. Let's list an interpretation of the network Global Analysis to make things clear:

Genes that are in the map but are not represented by SNPs in Opus 23 Pro are colored gray
Genes that contain solely SNPs for which the client genotype does not contain risk alleles are entirely colored green
Genes that contain solely SNPs for which the client genotype is homozygous for risk alleles are entirely colored orange
Genes that contain SNPs that have a mixture of different outcomes will display the outcomes as percentages of the SNP power factor
A gene with a mix of heterozygous and non-reactive SNPs of about equal significance will be half yellow and half green
A gene that has all three classes of outcomes represented will show orange, yellow and green colors

MAPPER results will display in the Chart Report if the 'Include Functional Analysis' is set to 'on' in the Report Options Screen (this is the default.) MAPPER elements display in the Chart Report under 'Functional Networks'. You can also select maps in the Chart Report for inclusion in the Client Report.

Clicking the 'Power Analysis' link at the top of the map changes the display to the Power Analysis view to estimate total gene function.

MAPPER gene functionality numbers are 'guesstimates' at best, since it is impossible to account for all factors contribution to the activity level of a gene. However, these numbers can be helpful in a broad sense.

Layout The Mapper uses standard network pathway symbols. Genes are in boxes with bold outlines, gene products, substrates and inhibitors are in boxes with grey outlines.

A line ending with a circle at a gene signifies that the molecule is metabolized by the gene or genes. Cofactors along the pathway that they assist are colored grey:

A line ending with an arrow signifies the direction of metabolism:

A line ending with a transverse line signifies inhibition: