 Help DocsPSYCHIC: Interactome based prescriptivesPSYCHIC allows you to search for natural products known to control gene expression. However, unlike a simple search engine, PSYCHIC is able to crawl up and down the molecular 'interactome' to determine the upstream and downstream genes that interact with the gene you've searched for. In addition PSYCHIC allows you to chose which type of natural products (agonists/ antagonists) to include in the upstream and downstream results. Getting around PSYCHIC From the 'Informatics' link on the main menu, hover over 'Prescriptives' until a second menu list appears, then select PSYCHIC. When the PSYCHIC screen loads you will be presented with the results of the default search term for the current client, the MTOR gene: PSYCHIC default screen As seen here the main infographic is comprised of a bar graph divided into two halves. The left half displays the upstream results, while the right half displays the downstream results, based on MTOR's position in the Interactome. The labels along the x-axis display the various natural products and their gene targets PSYCHIC has found that meet the search criteria. The y-axis value of each bar in the graph is determined by the evidence basis and strength of the position in the network for the gene depicted. You can set filters on each half of the graph to limit results to a specific type (agonism or antagonism) by selecting an option from the pull down menu below. There are four options:
To select a gene to run in PSYCHIC, simply begin typing in its gene symbol in the text input field; PSYCHIC will auto-complete the entry with any genes for which it has data. If multiple options are displayed, simply select the gene you wish to analyze. When you’re ready, press the 'Run Psychic' button to have PSYCHIC run results. |
