Datapunk Opus 23 Pro

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SUPERMOGADON: GWAS in words and pictures

SUPERMOGADON is a highly flexible search and sort tool that allows you to easily compare the client's genotype with results from Genome Wide Association Studies (GWAS) through the Opus 23 pro database. Just enter any term in the search box and SUPERMOGADON will return with the filtered results for that search term. Click on the graph icon to display SNP distribution for that pathology or trait as a Manhattan Plot. Click on any column title to sort by that column.

Getting around in SUPERMOGADON

From the 'Informatics' link on the main menu, hover over 'Analytics' until a second menu list appears, then select SUPERMOGADON.

As you can see there are over 50+ pages of GWAS data in SUPERMOGADON, which would make grinding through the data rather impractical. To deal with large amounts of data, SUPERMOGADON features a 'filterable' display. Type full or partial search terms into the search box at the upper left hand corner and SUPERMOGADON immediately displays only those results.

The SUPERMOGADON table displays the following data by column:

Pathology/ Trait
Specifics (metabolites, etc)
Total SNP hits in the GWAS database for the disease/trait
Total heterozygous results for client
Total Homozygous results for client
A synthesis of the aggregate log p value for the combination of heterozygous and homozygous; SNPs in the client's genome
Link to infographic depiction of SNPs for that trait

Click on the NOTEPAD icon to add or edit a note for that disease/ trait.

SUPERMOGADON columns are sortable. From the SUPERMOGADON index page click on any column title to sort by that column. Click that column again to reverse the sort order.

Manhattan plots in SUPERMOGADON

Clicking on the blue graph icon in the 'Show Plot' column will launch the SUPERMOGADON Manhattan plotter for that disease/trait. For example, click the graph for 'Inflammatory Bowel Disease' to get a GWAS Manhattan plot of 'Inflammatory Bowel Disease'.

The SUPERMOGADON Viewer is a GWAS Manhattan plotter, a type of scatter chart used to display data with a large number of data-points. Genomic SNP coordinates are displayed along the X-axis, with the negative logarithm of association P-value for the disease or pathology displayed on the Y-axis. Because the strongest associations have the smallest P-values (e.g., 10 −15), their negative logarithms will be the greatest (e.g., 15).

Client SNP genotypes results are shape and color-coded:

Gray-colored points denote client SNPs that do not contain the risk allele
Orange-colored points denote that the client is homozygous for the risk allele
Yellow-colored points denote that the client is heterozygous for the risk allele
Square-shaped points signify that the SNP is in the GWAS and Opus 23 Pro databases and when clicked will trigger an information pop-up
Circle-shaped points signify that the SNP is not in the Opus 23 Pro database but is in the GWAS database and is reported by 23andMe. When clicked these SNPs will bring up its GWAS PubMed reference article;

Drag-select to zoom section or use the scroller at the bottom. Hover over any point to learn more.

Like any other element in Opus 23 Pro, you can notate the SNP in SUPERMOGADON Viewer by clicking on the link to bring up the information pop-up, then clicking the 'Add/Edit Note' button at the top of the pop-up screen.